大鼠运动皮层在体阵发性神经元去极化：细胞内注射钙激动剂BAY K 8644
Paroxysmal neuronal depolarizations in the rat motorcortex in vivo: intracellular injection of the calcium agonist BAY K 8644.
作者信息
Walden J, Pockberger H, Speckmann E J, Petsche H
出版信息
Exp Brain Res. 1986;64(3):607-9. doi: 10.1007/BF00340500.
PMID:2433141
Abstract
Epileptic activity was elicited in the rat's motor cortex by local application of penicillin. At the neuronal level it consisted of typical paroxysmal depolarization shifts. The calcium agonist BAY K 8644 was injected into neurons showing such a discharge pattern. The application of this drug increased amplitude and after depolarization of paroxysmal neuronal depolarizations.
摘要
通过在大鼠运动皮层局部应用青霉素引发癫痫活动。在神经元水平上，它由典型的阵发性去极化偏移组成。将钙激动剂BAY K 8644注射到呈现这种放电模式的神经元中。该药物的应用增加了阵发性神经元去极化（的）幅度和去极化后电位。
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