BAY-K-8644是一种钙通道激动剂，可诱导甲状腺细胞胞质游离钙升高和碘释放。
BAY-K-8644, a calcium channel agonist, induces a rise in cytoplasmic free calcium and iodide discharge in thyroid cells.
作者信息
Takasu N, Murakami M, Nagasawa Y, Yamada T, Shimizu Y, Kojima I, Ogata E
出版信息
Biochem Biophys Res Commun. 1987 Mar 30;143(3):1107-11. doi: 10.1016/0006-291x(87)90366-4.
BAY-K-8644, a calcium channel agonist, induces a rise in cytoplasmic free calcium and iodide discharge in cultured porcine thyroid cells. The cytoplasmic free calcium concentration, [Ca2+]i, was measured using aequorin, a calcium-sensitive photoprotein. BAY-K-8644, a dihydropyridine derivative, acts as a Ca channel agonist and induces a rise in [Ca2+]i and iodide discharge; 0.5 nM BAY-K-8644 is a minimal dose to effect a rise in [Ca2+]i and iodide discharge and 50 nM BAY-K-8644 produces the maximal effect. The data indicate that BAY-K-8644-induced iodide discharge is mediated by a rise in [Ca2+]i.
BAY-K-8644是一种钙通道激动剂，可诱导培养的猪甲状腺细胞胞质游离钙升高和碘释放。使用水母发光蛋白（一种钙敏感光蛋白）测量胞质游离钙浓度[Ca2+]i。BAY-K-8644是一种二氢吡啶衍生物，作为钙通道激动剂，可诱导[Ca2+]i升高和碘释放；0.5 nM BAY-K-8644是使[Ca2+]i升高和碘释放的最小剂量，50 nM BAY-K-8644产生最大效应。数据表明，BAY-K-8644诱导的碘释放是由[Ca2+]i升高介导的。
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