Castle N A, Strong P N
FEBS Lett. 1986 Dec 1;209(1):117-21. doi: 10.1016/0014-5793(86)81095-x.
Two polypeptide toxins from scorpion (Leiurus quinquestriatus) venom which block distinct classes of calcium-activated potassium channels have been identified and partially purified. One toxin, at 50-100 ng/ml, blocks apamin-sensitive potassium fluxes in hepatocytes and inhibits [125I]monoiodoapamin binding. The other, more basic, toxin blocks apamin-insensitive potassium fluxes in erythrocytes at 200 ng/ml and, to our knowledge, is the first toxin shown to block the erythrocyte calcium-activated potassium channel with high affinity. The possible co-identity of this latter toxin with charybdotoxin is discussed.
已鉴定并部分纯化了两种来自蝎子（以色列金蝎）毒液的多肽毒素，它们可阻断不同类型的钙激活钾通道。一种毒素浓度为50 - 100 ng/ml时，可阻断肝细胞中对蜂毒明肽敏感的钾离子通量，并抑制[125I]单碘蜂毒明肽的结合。另一种碱性更强的毒素，浓度为200 ng/ml时可阻断红细胞中对蜂毒明肽不敏感的钾离子通量，据我们所知，它是第一种被证明能高亲和力阻断红细胞钙激活钾通道的毒素。本文还讨论了后一种毒素与大毒蜥毒素可能相同的情况。
