Le Cam G, Le Cam A
FEBS Lett. 1987 Jan 1;210(1):1-5. doi: 10.1016/0014-5793(87)81286-3.
Synthesis of the growth hormone-regulated anti-protease GHR-P63 by rat hepatocytes was strongly reduced during acute inflammation. This decrease was detected 8 h after the onset of inflammation and reached a maximum after 24 h. A decrease in the GHR-P63 mRNA level measured by in vitro translation and by hybridization mainly accounted for the alteration of GHR-P63 synthesis. Besides this major pretranslational mechanism, inflammation also interfered with GHR-P63 synthesis at a posttranslational level. This was indicated by the production of abnormal immunoprecipitable species at early stages of the acute-phase response.
在急性炎症期间，大鼠肝细胞合成生长激素调节的抗蛋白酶GHR-P63的能力大幅下降。炎症开始8小时后检测到这种下降，并在24小时后达到最大值。通过体外翻译和杂交测量的GHR-P63 mRNA水平下降主要是GHR-P63合成改变的原因。除了这种主要的翻译前机制外，炎症在翻译后水平也干扰了GHR-P63的合成。急性期反应早期产生异常的免疫沉淀产物表明了这一点。
