Sevaljević L, Krtolica K, Poznanović G, Marinković S, Bosković B
Life Sci. 1987 Aug 3;41(5):621-7. doi: 10.1016/0024-3205(87)90416-4.
The effect of lethal and repetitive sublethal soman intoxication on the composition of rat liver mRNA was examined by cell-free translation and hybridization. It was found that lethal as well as sustained sublethal soman poisoning of rats elicited a typical acute phase response as judged by a several-fold increase in levels of mRNAs coding for the major acute phase proteins and the vast number of systemic and metabolic changes creating the acute phase response should be taken into account when the metabolic events during the recovery from organophosphate intoxication are under consideration.
通过无细胞翻译和杂交技术，研究了致死性和重复性亚致死性梭曼中毒对大鼠肝脏mRNA组成的影响。结果发现，大鼠的致死性以及持续性亚致死性梭曼中毒引发了典型的急性期反应，这可通过编码主要急性期蛋白的mRNA水平增加数倍来判断。在考虑有机磷中毒恢复过程中的代谢事件时，应考虑到引发急性期反应的大量全身和代谢变化。
