Sachs F
Fed Proc. 1987 Jan;46(1):12-6.
Nothing is known of transduction mechanisms of baroreceptors in vivo. Not even the site of transduction is known. However, there are mechanotransducer ion channels that provide a useful model system of transduction. In these channels, transduction is accomplished by a strain-dependent increase in the probability of being open. Membrane tension is coupled to the channel by cytoskeletal strands that concentrate the strain energy from a large (approximately equal to 4000 A diameter) area of membrane and thereby provide high sensitivity. The channel is fast and does not inactivate, but viscoelastic coupling to the channel can dramatically alter the transfer function.
关于体内压力感受器的转导机制，目前尚不清楚。甚至转导位点也不为人知。然而，存在一些机械转导离子通道，它们提供了一个有用的转导模型系统。在这些通道中，转导是通过应变依赖性地增加开放概率来完成的。膜张力通过细胞骨架链与通道相连，这些细胞骨架链将来自大面积（直径约等于4000埃）膜的应变能量集中起来，从而提供高灵敏度。该通道快速且不会失活，但与通道的粘弹性耦合可显著改变传递函数。
