Shuler C F, Schwartz S A
Exp Cell Biol. 1986;54(5-6):301-9.
Although several types of modified stratified squamous epithelia are present in the adult mammal, most are presumably derived from similar embryonic progenitors. Mechanisms responsible for region-specific specialization are poorly understood. To correlate epithelial diversification with the expression of tissue-specific markers, we analyzed keratin protein composition in four representative types of rat squamous epithelia from early embryonic through adult phases of development. Keratin subsets synthesized in palatal mucosa were qualitatively similar, but differed dramatically in relative abundance. Tongue mucosa synthesized a different, but consistent subset of keratins which also changed quantitatively throughout morphogenesis. In contrast, different keratin genes were sequentially expressed during histogenesis of backskin and footpad epidermis. These data indicate that tissue-specific keratin biosynthesis is genetically predetermined early in embryogenesis.
虽然成年哺乳动物体内存在几种类型的改良复层鳞状上皮，但大多数可能源自相似的胚胎祖细胞。负责区域特异性特化的机制尚不清楚。为了将上皮细胞多样化与组织特异性标志物的表达相关联，我们分析了从胚胎早期到成年发育阶段的四种代表性大鼠鳞状上皮中角蛋白的蛋白质组成。腭黏膜中合成的角蛋白亚群在质量上相似，但相对丰度差异很大。舌黏膜合成了不同但一致的角蛋白亚群，在整个形态发生过程中其数量也发生变化。相比之下，背部皮肤和足垫表皮的组织发生过程中依次表达不同的角蛋白基因。这些数据表明，组织特异性角蛋白生物合成在胚胎发育早期就由基因预先决定。
