Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
Mol Cell. 2013 Dec 12;52(5):611-2. doi: 10.1016/j.molcel.2013.11.018.
In this issue of Molecular Cell, Aarke et al. (2013) identify a toxin-antitoxin system in Caulobacter crescentus that acts by a unique mechanism. The toxin, which blocks DNA replication, is constitutively degraded by ClpXP, and this degradation requires the antitoxin, a ClpXP adaptor.
在本期《分子细胞》中,Aarke 等人(2013 年)鉴定出一种存在于新月柄杆菌中的毒素-抗毒素系统,该系统通过一种独特的机制发挥作用。该毒素可阻断 DNA 复制,其降解是由 ClpXP 持续进行的,而这一降解过程需要抗毒素的参与,即 ClpXP 接头。