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一种自调控II型毒素-抗毒素系统调节……中的耐药性和毒力 。（原文句子不完整，缺少具体对象）

An Auto-Regulating Type II Toxin-Antitoxin System Modulates Drug Resistance and Virulence in .

作者信息

Gu Qibing, He Peijuan, Wang Dan, Ma Jiale, Zhong Xiaojun, Zhu Yinchu, Zhang Yue, Bai Qiankun, Pan Zihao, Yao Huochun

机构信息

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

Key Laboratory of Animal Bacteriology, Ministry of Agriculture, Nanjing, China.

出版信息

Front Microbiol. 2021 Aug 12;12:671706. doi: 10.3389/fmicb.2021.671706. eCollection 2021.

DOI:10.3389/fmicb.2021.671706
PMID:34475853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8406773/
Abstract

Toxin-antitoxin (TA) systems are ubiquitous genetic elements that play an essential role in multidrug tolerance and virulence . So far, little is known about the TA systems in . In this study, the Xress-MNTss TA system, composed of the MNTss toxin in the periplasmic space and its interacting Xress antitoxin, was identified in . β-galactosidase activity and electrophoretic mobility shift assay (EMSA) revealed that Xress and the Xress-MNTss complex could bind directly to the Xress-MNTss promoter as well as downregulate streptomycin adenylyltransferase . Interestingly, the Xress deletion mutant was less pathogenic following a challenge in mice. Transmission electron microscopy and adhesion assays pointed to a significantly thinner capsule but greater biofilm-formation capacity in Δ than in the wild-type strain. These results indicate that Xress-MNTss, a new type II TA system, plays an important role in antibiotic resistance and pathogenicity in .

摘要

毒素-抗毒素（TA）系统是普遍存在的遗传元件，在多药耐受性和毒力方面发挥着重要作用。到目前为止，关于[具体对象]中的TA系统知之甚少。在本研究中，在[具体对象]中鉴定出了Xress-MNTss TA系统，它由周质空间中的MNTss毒素及其相互作用的Xress抗毒素组成。β-半乳糖苷酶活性和电泳迁移率变动分析（EMSA）表明，Xress和Xress-MNTss复合物可以直接结合到Xress-MNTss启动子上，并下调链霉素腺苷酸转移酶。有趣的是，Xress缺失突变体在小鼠体内受到攻击后致病性较低。透射电子显微镜和黏附试验表明，与野生型菌株相比，Δ[具体对象]的荚膜明显更薄，但生物膜形成能力更强。这些结果表明，新型II型TA系统Xress-MNTss在[具体对象]的抗生素抗性和致病性中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/93b197f37760/fmicb-12-671706-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/bbc74063ce59/fmicb-12-671706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/8d6604c54f5e/fmicb-12-671706-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/9b47290f995e/fmicb-12-671706-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/5f29bfdd5bce/fmicb-12-671706-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/75ecdd398fd5/fmicb-12-671706-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/e63387c4d7bf/fmicb-12-671706-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/93b197f37760/fmicb-12-671706-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/bbc74063ce59/fmicb-12-671706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/8d6604c54f5e/fmicb-12-671706-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/9b47290f995e/fmicb-12-671706-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/5f29bfdd5bce/fmicb-12-671706-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/75ecdd398fd5/fmicb-12-671706-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/e63387c4d7bf/fmicb-12-671706-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b37a/8406773/93b197f37760/fmicb-12-671706-g007.jpg

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