黄酮混合物可改善感染布氏锥虫引起的 Wistar 大鼠红细胞渗透脆性和丙二醛浓度的增加。
Flavonoid mixture ameliorates increase in erythrocyte osmotic fragility and malondialdehyde concentration induced by Trypanosoma brucei brucei-infection in Wistar rats.
机构信息
Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria.
Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria.
出版信息
Res Vet Sci. 2014 Feb;96(1):139-42. doi: 10.1016/j.rvsc.2013.10.005. Epub 2013 Oct 30.
The experiment was performed with the aim of investigating the effect of a flavonoid mixture, Daflon® 500 mg (DF) on the erythrocyte fragility and lipoperoxidative changes, induced by Trypanosoma brucei brucei infection in Wistar rats. Fifty adult male rats randomly divided into five groups of 10 animals each were used. Rats in the control group were administered (1 mL/kg) distilled water only, while the other groups were infected with T. brucei brucei and treated with Daflon® 500 mg and/or Diminazene aceturate. At the end of 5 weeks, EDTA-blood samples and serum samples were collected from the rats, and were used to determine erythrocyte osmotic fragility (EOF) and serum malondialdehyde (MDA) concentration respectively. The results showed that EOF and MDA concentration significantly (P<0.05) increased in the infected untreated group when compared to the treatment groups. Treatment with Daflon® 500 mg and Diminazene aceturate significantly (P<0.05) reduced trypanosome-induced increases in EOF and lipoperoxidative changes, suggesting possible antioxidant properties of Daflon® 500 mg and its therapeutic value in trypanosomosis.
本实验旨在研究黄酮混合物 Daflon® 500mg（DF）对感染布氏锥虫的 Wistar 大鼠红细胞脆性和脂质过氧化变化的影响。使用 50 只成年雄性大鼠，随机分为 5 组，每组 10 只。对照组大鼠给予（1mL/kg）蒸馏水，而其他组感染布氏锥虫并给予 Daflon® 500mg 和/或Diminaazen 乙酰脲治疗。在 5 周结束时，从大鼠中采集 EDTA 血液样本和血清样本，用于分别测定红细胞渗透脆性（EOF）和血清丙二醛（MDA）浓度。结果表明，与治疗组相比，未治疗感染组的 EOF 和 MDA 浓度显著（P<0.05）升高。用 Daflon® 500mg 和 Diminaazen 乙酰脲治疗可显著（P<0.05）降低锥虫诱导的 EOF 和脂质过氧化变化，表明 Daflon® 500mg 具有抗氧化特性及其在锥虫病中的治疗价值。
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