Adeleye Olushola Emmanuel, Ale Jude Makinde, Sogebi Emmanuella Olubanke Amope, Durotoye Ladoke A, Adeleye Adenike Iyabo, Adeyemi Samuel Olufemi, Olukunle Johnny Olufemi
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
J Basic Clin Physiol Pharmacol. 2018 Jun 27;29(3):265-269. doi: 10.1515/jbcpp-2017-0201.
This study was carried out to determine the blood pressure changes in experimentally Trypanosoma brucei brucei-infected Wistar albino rats and diminazene aceturate-treated rats.
Twenty-four rats were purchased and divided into four groups consisting of six rats each. Control group (CON) received 0.5 mL of distilled water, i.m., infected but not treated group (INF) received 2×106 trypanosome/mL i.m., infected but diminazene aceturate-treated group (INFDIM) received 2×106 trypanosome/mL, 3.5 mg/kg, i.m.) and non-infected but diminazene aceturate-treated group (DIM) received 3.5 mg/kg, i.m. and served as negative control. The blood pressures were measured using a CODA 2® non-invasive blood pressure monitor (Kent Scientific, USA). The results were compiled and statistical analysis was done with significance set at p≥0.05.
The values of the blood pressure readings of the Trypanosoma-infected INF (137.0±2.0 mmHg) and diminazene-treated rats INFDIM (125.0±7.5 mmHg) when compared to the control group (168.0±3.0 mmHg) were significantly lower (p≤0.05) at the end of day 7. The heart rate was also significantly reduced in the INF (403.5±1.5 beats/min) and DIM (445.0±24 beats/min) groups of rats when compared with the control group (613.0±2.0 beats/min) at the end of day 8.
The findings indicate the significant reduction in blood pressure and heart rates during Trypanosoma brucei brucei infection and with diminazene aceturate administration. Hence, caution should be exercised when treating trypanosome-infected patients with diminazene aceturate.
本研究旨在确定实验性感染布氏布氏锥虫的Wistar白化大鼠以及接受乙酰氨基苯脒治疗的大鼠的血压变化。
购买24只大鼠，分为四组，每组6只。对照组（CON）肌肉注射0.5 mL蒸馏水，感染但未治疗组（INF）肌肉注射2×10⁶锥虫/mL，感染但接受乙酰氨基苯脒治疗组（INFDIM）肌肉注射2×10⁶锥虫/mL、3.5 mg/kg，未感染但接受乙酰氨基苯脒治疗组（DIM）肌肉注射3.5 mg/kg，作为阴性对照。使用CODA 2®无创血压监测仪（美国肯特科学公司）测量血压。汇总结果并进行统计分析，显著性设定为p≥0.05。
与对照组（168.0±3.0 mmHg）相比，感染锥虫的INF组（137.0±2.0 mmHg）和接受乙酰氨基苯脒治疗的INFDIM组（125.0±7.5 mmHg）在第7天结束时血压读数显著降低（p≤0.05）。与对照组（第8天结束时为613.0±2.0次/分钟）相比，INF组（403.5±1.5次/分钟）和DIM组（445.0±24次/分钟）大鼠的心率在第8天结束时也显著降低。
研究结果表明，布氏布氏锥虫感染期间以及给予乙酰氨基苯脒后，血压和心率显著降低。因此，在用乙酰氨基苯脒治疗锥虫感染患者时应谨慎。
