Department of Neurology, First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Lu, Nanning 530021, Guangxi, China.
Department of Cardiothoracic Surgery, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan, China.
J Clin Neurosci. 2014 Mar;21(3):390-4. doi: 10.1016/j.jocn.2013.07.019. Epub 2013 Dec 12.
Associations between apolipoprotein E (APOE) gene polymorphisms and Creutzfeldt-Jakob disease (CJD) have been reported, but the results from many of these studies are conflicting. To investigate the association between APOE polymorphisms and CJD risk, we performed a meta-analysis. We used odds ratios (OR) with 95% confidence intervals (CI) to assess the strength of the association. The frequency of putative risk alleles in control subjects was estimated with the Mantel-Haenszel method. Cochran's Q statistic and the inconsistency index (I(2)) were used to test heterogeneity. Egger's test and an inverted funnel plot were used to assess bias. Our study included 11 published case-control studies with APOE genotyping, involving a total of 1001 CJD patients and 1211 controls. Overall, the APOE 34 (OR 1.37, 95% CI: 1.09-1.72), and APOE 44 (OR 3.16, 95% CI: 1.37-7.26) genotypes and the APOE 4 (OR 1.41, 95% CI: 1.08-1.85) allele were associated with an increased risk of CJD, and the APOE 33 (OR 0.81, 95% CI: 0.67-0.97) genotype tended to protect against CJD. However, we did not find significant evidence supporting associations of the APOE 22 (OR 1.15, 95% CI: 0.45-2.93), APOE 23 (OR 0.84, 95% CI: 0.64-1.09), or APOE 24 (OR 1.40, 95% CI: 0.70-2.77) genotypes, nor the APOE 2 (OR 1.02, 95% CI: 0.73-1.42) or APOE 3 (OR 0.82, 95% CI: 0.65-1.02) alleles with CJD using a fixed-effects model. Our results support a genetic association between APOE polymorphisms and CJD.
载脂蛋白 E (APOE) 基因多态性与克雅氏病 (CJD) 之间存在关联，但这些研究的结果存在很大差异。为了研究 APOE 多态性与 CJD 风险之间的关系，我们进行了荟萃分析。我们使用比值比 (OR) 和 95%置信区间 (CI) 来评估关联的强度。采用 Mantel-Haenszel 法估计对照受试者中假定的风险等位基因的频率。采用 Cochran's Q 统计量和不一致指数 (I(2)) 来检验异质性。Egger 检验和倒漏斗图用于评估偏倚。我们的研究纳入了 11 项已发表的病例对照研究，其中包括 APOE 基因分型，共涉及 1001 例 CJD 患者和 1211 名对照。总体而言，APOE 34 (OR 1.37, 95% CI: 1.09-1.72)、APOE 44 (OR 3.16, 95% CI: 1.37-7.26) 基因型和 APOE 4 (OR 1.41, 95% CI: 1.08-1.85) 等位基因与 CJD 风险增加相关，而 APOE 33 (OR 0.81, 95% CI: 0.67-0.97) 基因型则倾向于预防 CJD。然而，我们没有发现支持 APOE 22 (OR 1.15, 95% CI: 0.45-2.93)、APOE 23 (OR 0.84, 95% CI: 0.64-1.09) 或 APOE 24 (OR 1.40, 95% CI: 0.70-2.77) 基因型，也没有支持 APOE 2 (OR 1.02, 95% CI: 0.73-1.42) 或 APOE 3 (OR 0.82, 95% CI: 0.65-1.02) 等位基因与 CJD 之间存在关联，采用固定效应模型。我们的结果支持 APOE 多态性与 CJD 之间存在遗传关联。
