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小鼠慢性泰勒氏病毒感染：脑脊液中髓鞘碱性蛋白的出现及针对MBP的血清抗体

Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP.

作者信息

Rauch H C, Montgomery I N, Hinman C L, Harb W, Benjamins J A

出版信息

J Neuroimmunol. 1987 Feb;14(1):35-48. doi: 10.1016/0165-5728(87)90099-3.

DOI:10.1016/0165-5728(87)90099-3
PMID:2433306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7119459/
Abstract

Myelin basic protein (MBP) appears frequently in the cerebrospinal fluid (CSF) of mice with chronic demyelination following intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV); antibody to MBP can frequently be found in the sera. The peaks of the immune responses to both MBP and TMEV coincide with the time course of the clinical signs of disease. Adsorption of mouse sera with TMEV or MBP indicate the non-identity of the antigens and the specificity of the antisera as measured by ELISA. Immunoblot analysis of sera confirmed the ELISA findings. The mechanism of induction of antibody directed against MBP and its role in TMEV-associated demyelination remain to be determined.

摘要

髓鞘碱性蛋白（MBP）经常出现在经泰勒鼠脑脊髓炎病毒（TMEV）脑内感染后发生慢性脱髓鞘的小鼠脑脊液（CSF）中；在血清中也经常能发现抗MBP抗体。对MBP和TMEV的免疫反应高峰与疾病临床症状的时间进程一致。用TMEV或MBP吸附小鼠血清表明抗原不同，且通过酶联免疫吸附测定（ELISA）检测的抗血清具有特异性。血清的免疫印迹分析证实了ELISA的结果。针对MBP的抗体诱导机制及其在TMEV相关脱髓鞘中的作用仍有待确定。

相似文献

1
Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP.小鼠慢性泰勒氏病毒感染：脑脊液中髓鞘碱性蛋白的出现及针对MBP的血清抗体
J Neuroimmunol. 1987 Feb;14(1):35-48. doi: 10.1016/0165-5728(87)90099-3.
2
Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination.II类限制性T细胞应答在泰勒氏鼠脑脊髓炎病毒（TMEV）诱导的脱髓鞘疾病中的作用。III. 神经抗原特异性免疫耐受未能影响脱髓鞘的临床进程。
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3
Serum and cells from Theiler's virus-infected mice fail to injure myelinating cultures or to produce in vivo transfer of disease. The pathogenesis of Theiler's virus-induced demyelination appears to differ from that of EAE.来自感染泰勒氏病毒小鼠的血清和细胞不会损伤髓鞘形成培养物，也不会导致疾病的体内传播。泰勒氏病毒诱导的脱髓鞘病变的发病机制似乎与实验性自身免疫性脑脊髓炎不同。
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6
Immunocytochemical localization of MAG, MBP and P0 protein in acute and relapsing demyelinating lesions of Theiler's virus infection.髓鞘相关糖蛋白、髓磷脂碱性蛋白和P0蛋白在泰勒氏病毒感染的急性和复发性脱髓鞘病变中的免疫细胞化学定位
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Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins.II类限制性T细胞应答在泰勒氏鼠脑脊髓炎病毒（TMEV）诱导的脱髓鞘疾病中的作用。I. TMEV毒株及相关微小核糖核酸病毒之间的交叉特异性，但髓磷脂蛋白之间不存在交叉特异性。
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