INSERM U932, 26 rue d'Ulm, 75005 Paris, France; Institut Curie, Section Recherche, 26 rue d'Ulm, 75005 Paris, France.
INSERM U932, 26 rue d'Ulm, 75005 Paris, France; Institut Curie, Section Recherche, 26 rue d'Ulm, 75005 Paris, France.
Immunol Lett. 2014 Mar-Apr;158(1-2):73-8. doi: 10.1016/j.imlet.2013.12.001. Epub 2013 Dec 12.
Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. Several murine DC subsets differ in their phenotype and functional properties, in particular in their ability to cross-present antigens (i.e. to present exogenous antigens on their MHC class I molecules). In humans, distinct DC subpopulations have also been identified but whether some human DC subsets are also specialized at cross-presentation remains debated. Here we review the DC subsets that have been identified in humans and we discuss recent work that addresses their ability to cross-present antigens and their efficiency for CD8(+) T cells activation.
树突状细胞 (DCs) 是一类异质性的专业抗原提呈细胞。几种小鼠 DC 亚群在表型和功能特性上存在差异，特别是在其交叉呈递抗原的能力（即在 MHC I 类分子上呈递外源抗原）上存在差异。在人类中，也已经鉴定出不同的 DC 亚群，但某些人类 DC 亚群是否也专门进行交叉呈递仍存在争议。本文综述了已在人类中鉴定出的 DC 亚群，并讨论了最近关于它们交叉呈递抗原的能力及其对 CD8+T 细胞激活效率的研究工作。
