Department of Laboratory Medicine, Immunobiology, Section of Allergy & Immunology, Yale University School of Medicine, New Haven, CT, USA.
Nat Rev Immunol. 2019 Feb;19(2):89-103. doi: 10.1038/s41577-018-0088-1.
Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity. They integrate signals derived from tissue infection or damage and present processed antigen from these sites to naive T cells in secondary lymphoid organs while also providing multiple soluble and surface-bound signals that help to guide T cell differentiation. DC-mediated tailoring of the appropriate T cell programme ensures a proper cascade of immune responses that adequately targets the insult. Recent advances in our understanding of the different types of DC subsets along with the cellular organization and orchestration of DC and lymphocyte positioning in secondary lymphoid organs over time has led to a clearer understanding of how the nature of the T cell response is shaped. This Review discusses how geographical organization and ordered sequences of cellular interactions in lymph nodes and the spleen regulate immunity.
树突状细胞 (DCs) 可以被视为先天免疫和适应性免疫之间的翻译者。它们整合来自组织感染或损伤的信号，并将这些部位的加工抗原呈递给次级淋巴器官中的幼稚 T 细胞，同时还提供多种可溶性和表面结合的信号，有助于指导 T 细胞分化。DC 介导的适当 T 细胞程序的定制确保了适当的免疫反应级联，从而充分针对损伤。我们对不同类型的 DC 亚群的理解的最新进展，以及 DC 和淋巴细胞在次级淋巴器官中的细胞组织和协调随时间的推移，使我们更清楚地了解 T 细胞反应的性质是如何形成的。本综述讨论了淋巴结和脾脏中的地理组织和细胞相互作用的有序序列如何调节免疫。
