Department of Psychology, Tufts University, Medford, MA 02155,USA.
Department of Psychology, Tufts University, Medford, MA 02155,USA.
Pharmacol Biochem Behav. 2014 Feb;117:34-9. doi: 10.1016/j.pbb.2013.12.002. Epub 2013 Dec 10.
The effects of intraperitoneal (ip) D-glucose administration on antinociception were studied in male Long-Evans rats. Rats were assessed for antinociception using the hot-water tail-withdrawal procedure (54±0.2 °C) to determine if peripheral administration of D-glucose (300, 560, or 720 mg/kg) would enhance morphine-mediated antinociception (MMA) (1.0, 3.0, 4.2, 5.6, and 10.0mg/kg cumulative-dosing regime) and if D-glucose (560, 720, or 1000 mg/kg) alone could produce antinociceptive activity that was naloxone (0.32 mg/kg) reversible. Additionally, the actions of D-glucose on MMA were compared with a stereoisomer, L-glucose, which is not metabolized. The results of these studies demonstrate that peripheral administration of D-glucose significantly enhances MMA and that D-glucose alone produces antinociceptive actions that are potentially mediated by the endogenous opioid system. Furthermore, L-glucose failed to have an effect on MMA suggesting that the alterations in antinociception seen with D-glucose are not due to stressors such as osmolality or injection. The current studies provide evidence that D-glucose alteration of antinociception is not simply a response to taste or gustation.
研究了腹腔内（ip）D-葡萄糖给药对雄性 Long-Evans 大鼠的镇痛作用。使用热水尾巴撤离程序（54±0.2°C）评估大鼠的镇痛作用，以确定外周给予 D-葡萄糖（300、560 或 720mg/kg）是否会增强吗啡介导的镇痛作用（MMA）（1.0、3.0、4.2、5.6 和 10.0mg/kg 累积剂量方案），以及 D-葡萄糖（560、720 或 1000mg/kg）本身是否可以产生阿片类内源性系统介导的镇痛作用，且这种作用可被纳洛酮（0.32mg/kg）逆转。此外，还比较了 D-葡萄糖对 MMA 的作用与非代谢的立体异构体 L-葡萄糖的作用。这些研究的结果表明，外周给予 D-葡萄糖可显著增强 MMA，且 D-葡萄糖本身可产生镇痛作用，这些作用可能由内源性阿片类系统介导。此外，L-葡萄糖对 MMA 没有影响，这表明 D-葡萄糖引起的镇痛作用的改变不是由于渗透压或注射等应激源引起的。目前的研究提供了证据，表明 D-葡萄糖对镇痛作用的改变不仅仅是对味觉或味觉的一种反应。
