将创伤后应激和物质使用障碍的病理学联系起来：单胺类和神经肽。
Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides.
机构信息
Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.
出版信息
Pharmacol Biochem Behav. 2014 Feb;117:61-9. doi: 10.1016/j.pbb.2013.12.001. Epub 2013 Dec 11.
Abstract
Posttraumatic stress disorder (PTSD) co-occurs highly with substance use disorders (SUDs), yet the neurobiological basis for this comorbid relationship remains unclear. PTSD and SUDs result in similar pathological states including impulsive behavior, reward deficiency, and heightened stress sensitivity. Hence, PTSD and SUD may depend on overlapping dysfunctional neurocircuitry. Here we provide a short overview of the relationship between comorbid PTSD and SUD, as well as the potential role of select neurotransmitter systems that may underlie enhanced vulnerability to drug abuse in the context of PTSD.
摘要
创伤后应激障碍（PTSD）与物质使用障碍（SUD）高度共病，但这种共病关系的神经生物学基础仍不清楚。PTSD 和 SUD 导致类似的病理状态，包括冲动行为、奖励不足和应激敏感性增加。因此，PTSD 和 SUD 可能依赖于重叠的功能障碍神经回路。在这里，我们简要概述了共患 PTSD 和 SUD 之间的关系，以及在 PTSD 背景下可能导致对药物滥用易感性增强的特定神经递质系统的潜在作用。
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