Center for Molecular and Behavioral Neuroscience, Rutgers State University Newark, NJ, USA.
Front Neurosci. 2013 May 31;7:89. doi: 10.3389/fnins.2013.00089. eCollection 2013.
Post-traumatic stress disorder (PTSD) is a debilitating condition that develops in a proportion of individuals following a traumatic event. Despite recent advances, ethical limitations associated with human research impede progress in understanding PTSD. Fortunately, much effort has focused on developing animal models to help study the pathophysiology of PTSD. Here, we provide an overview of animal PTSD models where a variety of stressors (physical, psychosocial, or psychogenic) are used to examine the long-term effects of severe trauma. We emphasize models involving predator threat because they reproduce human individual differences in susceptibility to, and in the long-term consequences of, psychological trauma.
创伤后应激障碍（PTSD）是一种在创伤事件发生后，一部分人会患上的使人虚弱的疾病。尽管最近取得了一些进展，但与人有关的研究的伦理限制阻碍了对 PTSD 的理解。幸运的是，人们已经投入了大量精力开发动物模型，以帮助研究 PTSD 的病理生理学。在这里，我们概述了 PTSD 的动物模型，其中使用了各种应激源（生理的、心理社会的或心理的）来检查严重创伤的长期影响。我们强调涉及捕食者威胁的模型，因为它们再现了人类对心理创伤的易感性以及长期后果的个体差异。
