早期小鼠胚胎中的谱系特化。

Lineage specification in the early mouse embryo.

机构信息

Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Karolinska Universitetssjukhuset, K 57 CLINTEC, 141 86 Stockholm, Sweden.

出版信息

Exp Cell Res. 2014 Feb 1;321(1):32-9. doi: 10.1016/j.yexcr.2013.12.004. Epub 2013 Dec 11.

DOI:10.1016/j.yexcr.2013.12.004

PMID:24333597

Abstract

Before the mammalian embryo is ready to implant in the uterine wall, the single cell zygote must divide and differentiate into three distinct tissues; trophectoderm (prospective placenta), primitive endoderm (prospective yolk sac), and pluripotent epiblast cells which will form the embryo proper. In this review I will discuss our current understanding of how positional information, cell polarization, signaling pathways, and transcription factor networks converge to drive and regulate the progressive segregation of the first three cell types in the mouse embryo.

摘要

在哺乳动物胚胎准备植入子宫壁之前，单细胞受精卵必须分裂并分化为三种不同的组织：滋养外胚层（潜在胎盘）、原始内胚层（潜在卵黄囊）和多能的上胚层细胞，它们将形成胚胎本身。在这篇综述中，我将讨论我们目前对如何理解位置信息、细胞极化、信号通路和转录因子网络如何汇聚，以驱动和调节小鼠胚胎中最初的三种细胞类型的渐进性分离的理解。