癌症干细胞：一个有争议的假说正在向前推进。

Cancer stem cells: A contentious hypothesis now moving forward.

机构信息

School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.

Cancer Care Centre, St. George Hospital, and St. George Clinical School, Faculty of Medicine, University of New South Wales, Kensington, NSW 2052, Australia.

出版信息

Cancer Lett. 2014 Mar 28;344(2):180-7. doi: 10.1016/j.canlet.2013.11.012. Epub 2013 Dec 11.

DOI:10.1016/j.canlet.2013.11.012

PMID:24333726

Abstract

Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.

摘要

癌症干细胞是一个不断发展的概念，旨在解释癌症的细胞生物学特性。尽管癌症干细胞模型存在争议，但它有可能为针对癌症根源的新创新治疗方法提供基础。在过去的两年中，癌症干细胞研究取得了非凡的进展，特别是在实体肿瘤方面，这为改善治疗效果带来了希望。在这里，我们回顾了癌症干细胞研究的最新进展，讨论了该领域的挑战，并探讨了克服化疗耐药性的癌症干细胞研究的未来策略和机遇。