Core Research Facilities (CRF), Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Department of Pharmaceutical Biology and Biotechnology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Cells. 2023 Nov 26;12(23):2713. doi: 10.3390/cells12232713.
Overcoming drug resistance and specifically targeting cancer stem cells (CSCs) are critical challenges in improving cancer therapy. Nowadays, the use of novel and native medicinal plants can provide new sources for further investigations for this purpose. The aim of this study was to assess the potential of , an endemic plant with diverse medicinal applications, in suppressing and targeting cancer and cancer stem cells in glioblastoma and breast cancer. The effect of on viability, migration, invasion, and clonogenic potential of MDAMB-231 and U87-MG cells was assessed in both two- and three-dimensional cell culture models. Additionally, we evaluated its effects on the self-renewal capacity of mammospheres. The experimental outcomes indicated that decreased the viability and growth rate of cells and spheroids by inducing apoptosis and inhibited colony formation, migration, and invasion of cells and spheroids. Additionally, colony and sphere-forming ability, as well as the expression of genes associated with EMT and stemness were reduced in mammospheres treated with . In conclusion, this study provided valuable insights into the anti-cancer effects of , particularly in relation to breast CSCs. Therefore, may be a potential adjuvant for the treatment of cancer.
克服耐药性和靶向肿瘤干细胞（CSC）是改善癌症治疗的关键挑战。如今，新型和本地药用植物的使用可以为这一目的的进一步研究提供新的来源。本研究旨在评估 ，一种具有多种药用应用的特有植物，在抑制和靶向脑胶质瘤和乳腺癌中的癌症和肿瘤干细胞方面的潜力。我们在二维和三维细胞培养模型中评估了 对 MDAMB-231 和 U87-MG 细胞活力、迁移、侵袭和克隆形成能力的影响。此外，我们还评估了它对类器官自我更新能力的影响。实验结果表明， 通过诱导细胞凋亡， 降低了细胞和球体的活力和生长速度，并抑制了细胞和球体的集落形成、迁移和侵袭。此外，用 处理的类器官中，与 EMT 和干性相关的基因的集落和球体形成能力以及表达水平均降低。总之，本研究深入了解了 的抗癌作用，特别是与乳腺癌 CSC 相关的作用。因此， 可能是癌症治疗的一种潜在辅助药物。
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