Ito M, Maeda Y, Arita M, Ito S, Saikawa T, Omura I, Fujino T, Fukumoto T, Kikuchi Y, Yamada K
J Electrocardiol. 1986 Jan;19(1):59-66. doi: 10.1016/s0022-0736(86)80008-5.
The effects of oral diltiazem (90-180 mg/day for four weeks) on ventricular premature contractions (VPCs) were studied in 16 patients with frequent VPCs using 24-hour ambulatory ECG recordings. VPC frequency was evaluated as a function of underlying heart rate. Plots of VPC frequency vs. heart rate were made at 1-beat/min intervals for all heart rates recorded for at least five minutes during 24 hours. Patterns of correlation between VPC frequency and heart rate observed before diltiazem therapy included: 1) a relatively linear increase in VPCs with heart rate (positive correlation) in ten patients, 2) a linear decrease (negative correlation) in one patient, and 3) an increase at low heart rates and a decrease at high heart rates (bidirectional correlation) in five patients. Diltiazem significantly reduced the mean VPC frequency per 24 hours for patients with a positive correlation, but induced no significant change for patients with a negative or a bidirectional correlation. At the 65% level of VPC reduction, diltiazem was effective in eight of ten patients with a positive correlation but was not effective in the six patients with other correlations (p less than 0.01). These results suggest that an evaluation of VPC frequency as a function of heart rate predicts the response of VPCs to diltiazem.
采用24小时动态心电图记录，对16例频发室性早搏患者研究了口服地尔硫䓬（90 - 180毫克/天，共四周）对室性早搏（VPC）的影响。室性早搏频率根据基础心率进行评估。在24小时内至少记录五分钟的所有心率下，以每分钟1次心跳的间隔绘制室性早搏频率与心率的关系图。地尔硫䓬治疗前观察到的室性早搏频率与心率之间的相关模式包括：1）10例患者中室性早搏随心率呈相对线性增加（正相关），2）1例患者呈线性下降（负相关），3）5例患者在低心率时增加而在高心率时下降（双向相关）。地尔硫䓬显著降低了正相关患者每24小时的平均室性早搏频率，但对负相关或双向相关患者未引起显著变化。在室性早搏减少65%的水平上，地尔硫䓬对10例正相关患者中的8例有效，但对6例其他相关性患者无效（p小于0.01）。这些结果表明，根据心率评估室性早搏频率可预测室性早搏对地尔硫䓬的反应。
