Müller Linda, Kollár Eszter, Balogh Lajos, Pöstényi Zita, Márián Teréz, Garai Ildikó, Balkay László, Trencsényi György, Thuróczy Julianna
Szent István University Department and Clinic of Obstetrics and Animal Reproduction, Faculty of Veterinary Science István u. 2 Budapest H-1078 Hungary.
National Frédéric Joliot-Curie Institute of Radiobiology and Radiohygiene Budapest Hungary.
Acta Vet Hung. 2014 Jun;62(2):169-79. doi: 10.1556/AVet.2013.057.
The relationship between metabolic disorders and the distribution of fat in different body regions is not clearly understood in humans. The aim of this study was to develop a suitable method for assessing the regional distribution of fat deposits and their metabolic effects in dogs. Twenty-five dogs were subjected to computed tomographic (CT) imaging and blood sampling in order to characterise their metabolic status. The different fat areas were measured on a cross-sectional scan, and the animals' metabolic status was evaluated by measuring fasting glucose, insulin and leptin levels. The volume of visceral adipose tissue is the main determinant of leptin levels. The correlation of visceral fat volume and leptin concentration was found to be independent of insulin levels or the degree of insulin resistance. There was a positive correlation between the visceral to subcutaneous fat volume ratio and serum insulin concentration, and a similar trend was observed in the relationship of fat ratio and insulin resistance. The distribution of body fat essentially influences the metabolic parameters in dogs, but the effects of adiposity differ between humans and dogs. The findings can facilitate a possible extrapolation of results from animal studies to humans with regard to the metabolic consequences of different obesity types.
在人类中，代谢紊乱与不同身体部位脂肪分布之间的关系尚不清楚。本研究的目的是开发一种合适的方法，用于评估犬类脂肪沉积的区域分布及其代谢效应。对25只犬进行计算机断层扫描（CT）成像和血液采样，以表征它们的代谢状态。在横断面扫描上测量不同的脂肪区域，并通过测量空腹血糖、胰岛素和瘦素水平来评估动物的代谢状态。内脏脂肪组织的体积是瘦素水平的主要决定因素。发现内脏脂肪体积与瘦素浓度的相关性独立于胰岛素水平或胰岛素抵抗程度。内脏与皮下脂肪体积比与血清胰岛素浓度之间存在正相关，在脂肪比与胰岛素抵抗的关系中也观察到类似趋势。身体脂肪的分布本质上会影响犬类的代谢参数，但肥胖的影响在人类和犬类之间有所不同。这些发现有助于将动物研究结果外推至人类，以了解不同肥胖类型的代谢后果。
