Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Invest Ophthalmol Vis Sci. 2014 Jan 7;55(1):117-24. doi: 10.1167/iovs.13-13290.
We examined the association of corneal hysteresis (CH) with Heidelberg retina tomograph (HRT)- and Glaucoma Detection with Variable Corneal Compensation scanning laser polarimeter (GDxVCC)-derived measures in a British population.
The EPIC-Norfolk Eye Study is nested within a multicenter cohort study--the European Prospective Investigation of Cancer. Ocular response analyzer (ORA), HRT3, and GDxVCC measurements were taken at the research clinic. Three ORA measurements were taken per eye, and the single best value used. Participants meeting predefined criteria were referred for a second examination, including Goldmann applanation tonometry (GAT) and central corneal thickness (CCT) measurement. Generalized estimating equation models were used to examine the associations of CH with HRT and GDxVCC parameters, adjusted for disc area. The GDxVCC analyses were adjusted further for typical scan score to handle atypical retardation.
There were complete research clinic data from 5134 participants. Corneal hysteresis was associated positively with HRT rim area (P < 0.001), and GDxVCC retinal nerve fiber layer (RNFL) average thickness (P = 0.006) and modulation (P = 0.003), and associated negatively with HRT linear cup-to-disc ratio (LCDR, P < 0.001), after adjustment for Goldmann-correlated IOP and other possible confounders. In the 602 participants undergoing the second examination, CH was associated negatively with LCDR (P = 0.008) after adjustment for GAT, CCT, and other possible confounders.
Lower CH was associated with HRT and GDxVCC parameters in a direction that is seen in glaucoma and with ageing. Further research is required to establish if this is a causal relationship, or due to residual confounding by age, IOP, or CCT.
我们研究了英国人群中角膜滞后（CH）与海德堡视网膜断层扫描仪（HRT）和青光眼检测变量角膜补偿扫描激光偏振仪（GDxVCC）衍生测量值的相关性。
EPIC-Norfolk 眼部研究嵌套在多中心队列研究——欧洲癌症前瞻性调查中。在研究诊所进行了眼反应分析仪（ORA）、HRT3 和 GDxVCC 测量。每只眼进行了三次 ORA 测量，使用单次最佳值。符合预设标准的参与者被转介进行第二次检查，包括 Goldmann 压平眼压计（GAT）和中央角膜厚度（CCT）测量。使用广义估计方程模型，调整视盘面积后，研究 CH 与 HRT 和 GDxVCC 参数的相关性。GDxVCC 分析进一步调整为典型扫描评分，以处理异常延迟。
共有 5134 名参与者完成了完整的研究诊所数据。CH 与 HRT 边缘面积呈正相关（P<0.001），与 GDxVCC 视网膜神经纤维层（RNFL）平均厚度（P=0.006）和调制（P=0.003）呈正相关，与 HRT 线性杯盘比（LCDR，P<0.001）呈负相关，在调整了 Goldmann 相关眼压和其他可能的混杂因素后。在接受第二次检查的 602 名参与者中，在调整了 GAT、CCT 和其他可能的混杂因素后，CH 与 LCDR 呈负相关（P=0.008）。
在青光眼和衰老过程中，较低的 CH 与 HRT 和 GDxVCC 参数呈负相关。需要进一步研究以确定这是否是因果关系，还是由于年龄、眼压或 CCT 的残余混杂因素所致。
