Department of Clinical Respiratory Sciences, Centre for Translational Inflammation and Fibrosis Research, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
Comprehensive Pneumology Center, University Hospital, Ludwig-Maximilians University and Helmholtz Zentrum, München, Germany.
Thorax. 2014 Aug;69(8):760-5. doi: 10.1136/thoraxjnl-2013-204608. Epub 2013 Dec 12.
Epithelial-mesenchymal transition (EMT) is a process when epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders, fibrotic tissue remodelling to lung cancer. The most important question--namely what is the importance and contribution of EMT in the pathogenesis of several chronic lung conditions (asthma, COPD, bronchiolitis obliterans syndrome and lung fibrosis)--is currently intensely debated. This review gives a brief insight into the mechanism and assessment methods of EMT in various pulmonary diseases and summarises the recent literature highlighting the controversial experimental data and conclusions.
上皮-间充质转化（EMT）是上皮细胞逐渐转化为具有间充质样表型的细胞，丧失上皮细胞功能和特征的过程。EMT 被认为与许多肺部疾病的发病机制有关，从发育障碍、纤维组织重塑到肺癌。目前，人们正在激烈争论的一个最重要的问题是 EMT 在几种慢性肺部疾病（哮喘、COPD、闭塞性细支气管炎综合征和肺纤维化）发病机制中的重要性和作用。这篇综述简要介绍了 EMT 在各种肺部疾病中的机制和评估方法，并总结了最近的文献，突出了有争议的实验数据和结论。
Zotero 插件