Sekiguchi Naohiro, Noto Satoshi, Wagatsuma Miyuki, Midorikawa Kiyoe, Tezuka Shunsuke, Hagino Takeshi, Saito Ikuo, Yamada Kazuaki, Takezako Naoki, Miwa Akiyoshi
Division of Hematology, National Hospital Organization Disaster Medical Center, Japan.
Intern Med. 2013;52(24):2801-4. doi: 10.2169/internalmedicine.52.0244.
Extramedullary hematopoietic effusion (EHE) is recognized to be an unusual phenomenon accompanied by hematologic disorders. Only a few reports are available of EHE occurring in patients with lymphoma. We herein report the case of a 54-year-old man with follicular lymphoma. Bone marrow aspirates and biopsied specimens showed diffuse invasion of small cleaved atypical lymphoid cells that were positive for CD10, 20, bcl2, immunoglobulin lambda and Bcl-2-IgH rearrangement. The pleural effusion aspirates and a biopsied specimen obtained via thoracoscopy revealed megakaryocytes and immature myeloid cells in addition to lymphoma cells. To the best of our knowledge, this is the first report of EHE accompanied by lymphoma according to the World Health Organization classification.
髓外造血性积液（EHE）被认为是一种伴随血液系统疾病的罕见现象。仅有少数关于淋巴瘤患者发生EHE的报道。我们在此报告一例54岁的滤泡性淋巴瘤男性患者。骨髓穿刺和活检标本显示小裂核非典型淋巴样细胞弥漫浸润，这些细胞CD10、20、bcl2、免疫球蛋白λ及Bcl-2-IgH重排均呈阳性。胸腔积液穿刺物及经胸腔镜获取的活检标本除淋巴瘤细胞外，还发现了巨核细胞和未成熟髓样细胞。据我们所知，这是世界卫生组织分类中首例伴有淋巴瘤的EHE报告。
