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华氏巨球蛋白血症中的髓外造血性胸腔积液。

Extramedullary hematopoietic pleural effusion in Waldenström's macroglobulinemia.

作者信息

Ito Kenichi, Harada Kunihiko, Uchino Yoshihito, Hirano Kazuhiko, Sekiguchi Naohiro

机构信息

Hematology Division National Hospital Organization Disaster Medical Center Tokyo Japan.

Laboratory and Pathology Division National Hospital Organization Disaster Medical Center Tokyo Japan.

出版信息

EJHaem. 2023 Jul 6;4(3):833-836. doi: 10.1002/jha2.754. eCollection 2023 Aug.

DOI:10.1002/jha2.754
PMID:37601852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10435710/
Abstract

Extramedullary hematopoietic effusion (EHE) is one of the extremely rare phenomena associated with extramedullary hematopoiesis, which is caused by serous effusions, including pleural effusion, and may be related to hematologic disorders and neoplasms. Herein, we present the case of an 81-year-old man with EHE accompanying Waldenström's macroglobulinemia (WM). The patient complained of anemia and dyspnea. The chest X-ray and computed tomography showed a massive left pleural effusion, and the aspirates revealed infiltration of the immature myeloid cells and megakaryocytes, in addition to the lymphoma cells. To our knowledge, this is the first report of EHE in WM.

摘要

髓外造血性积液（EHE）是与髓外造血相关的极为罕见的现象之一，它由浆液性积液引起，包括胸腔积液，可能与血液系统疾病和肿瘤有关。在此，我们报告一例81岁男性患者，其患有伴有华氏巨球蛋白血症（WM）的EHE。患者主诉贫血和呼吸困难。胸部X线和计算机断层扫描显示左侧大量胸腔积液，抽吸物除淋巴瘤细胞外，还显示未成熟髓样细胞和巨核细胞浸润。据我们所知，这是WM中EHE的首例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614d/10435710/397c44ad90c1/JHA2-4-833-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614d/10435710/b050a9974f33/JHA2-4-833-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614d/10435710/5f3a680b9d1c/JHA2-4-833-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614d/10435710/397c44ad90c1/JHA2-4-833-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614d/10435710/b050a9974f33/JHA2-4-833-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614d/10435710/5f3a680b9d1c/JHA2-4-833-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614d/10435710/397c44ad90c1/JHA2-4-833-g002.jpg

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Br J Haematol. 2021 Mar;192(5):843-852. doi: 10.1111/bjh.17028. Epub 2020 Aug 11.
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Extramedullary hematopoiesis in the absence of myeloproliferative neoplasm: Mayo Clinic case series of 309 patients.
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Gene Expression Profile Signature of Aggressive Waldenström Macroglobulinemia with Chromosome 6q Deletion.伴有 6q 缺失的侵袭性华氏巨球蛋白血症的基因表达谱特征。
Biomed Res Int. 2018 Oct 4;2018:6728128. doi: 10.1155/2018/6728128. eCollection 2018.
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