Taniguchi T, Fujiwara M, Masuo Y, Kanazawa I
Jpn J Pharmacol. 1986 Dec;42(4):590-3. doi: 10.1254/jjp.42.590.
We investigated the contents of neurokinin A, neurokinin B and substance P in the rabbit iris sphincter muscle, combining HPLC and radioimmunoassay, as our previous reports indicated that a slow component of neurogenic contractions of this muscle is most probably mediated by such tachykinins. The concentrations of these tachykinins were 44.3 +/- 8.7 fmol/mg protein, 35.3 +/- 10.2 fmol/mg protein and 186.8 +/- 29.8 fmol/mg protein (N = 4), respectively. These results demonstrated that neurokinin A, neurokinin B and substance P are all present in the rabbit iris sphincter muscle.
我们结合高效液相色谱法（HPLC）和放射免疫分析法，对兔虹膜括约肌中神经激肽A、神经激肽B和P物质的含量进行了研究，因为我们之前的报告表明，该肌肉神经源性收缩的慢成分很可能由这些速激肽介导。这些速激肽的浓度分别为44.3±8.7 fmol/mg蛋白质、35.3±10.2 fmol/mg蛋白质和186.8±29.8 fmol/mg蛋白质（N = 4）。这些结果表明，神经激肽A、神经激肽B和P物质均存在于兔虹膜括约肌中。
