Evans D B
J Cardiovasc Pharmacol. 1986;8 Suppl 9:S22-9.
Modulation of intracellular cAMP in cardiac cells results in a positive inotropic effect. This effect is achieved by increasing intracellular cAMP, via a variety of ways, which leads to the phosphorylation of proteins in the sarcolemma, sarcoplasmic reticulum, and contractile filaments. This phosphorylation alters calcium metabolism in the cell to effect an increase in the influx of extracellular calcium, an increase in sarcoplasmic reticulum uptake of calcium, and an altered sensitivity of the contractile proteins to calcium. These changes in cellular metabolism of calcium effect an increase in cardiac contractility which is associated with an increase in rate of both contraction and relaxation.
调节心脏细胞内的环磷酸腺苷（cAMP）会产生正性肌力作用。这种作用是通过多种方式增加细胞内cAMP来实现的，这会导致肌膜、肌浆网和收缩细丝中的蛋白质磷酸化。这种磷酸化改变细胞内的钙代谢，从而增加细胞外钙的内流、肌浆网对钙的摄取，并改变收缩蛋白对钙的敏感性。细胞钙代谢的这些变化导致心脏收缩力增加，这与收缩和舒张速率的增加有关。
