Tsuda T, Kubota K, Yasuda K, Nishikawa S, Sugaya A, Sugaya E
J Ethnopharmacol. 1986 Sep;17(3):257-61. doi: 10.1016/0378-8741(86)90113-3.
The Chinese herbal medicine, "Kanbaku-taiso-to" (KT) which is a mixture of Glycyrrhizae Radix, Triticii Semen and Zizyphi Fructus, sometimes shows marked effects on insomnia, infantile convulsions and emotional irritability. To elucidate the mechanism of the sedative effect of KT, effects of KT on the transmembrane ionic currents and local anesthetic action were examined and the following results were obtained. KT showed an inhibition of sodium, calcium and potassium currents in snail neurons. KT showed an inhibitory effect on pentylenetetrazol-induced bursting activity. KT had local anesthetic action on frog nerve fibers. Together with our previous study, these results suggest that KT has an inhibitory effect on hyperexcitability of the neuronal membrane and this is the main cause of the sedative effect of KT.
中药“甘麦大枣汤”（KT）由甘草、小麦和大枣混合而成，有时对失眠、小儿惊厥和情绪烦躁有显著疗效。为阐明KT的镇静作用机制，研究了KT对跨膜离子电流和局部麻醉作用的影响，得到以下结果。KT对蜗牛神经元的钠、钙和钾电流有抑制作用。KT对戊四氮诱导的爆发活动有抑制作用。KT对青蛙神经纤维有局部麻醉作用。结合我们之前的研究，这些结果表明KT对神经元膜的过度兴奋有抑制作用，这是KT产生镇静作用的主要原因。
