Mainetti S, Carnevali F
DM Specialist in Anesthesiology and Emergency Medicine, Santo Spirito Hospital, Rome, Italy.
DVM Researcher, ENEA Casaccia Research Centre, Rome, Italy.
J Wound Care. 2013 Dec;22(12):681-2, 684-5, 688-9. doi: 10.12968/jowc.2013.22.12.681.
To observe the efficacy of a plant-derived wound dressing (1 Primary Wound Dressing®), a mixture of hypericum and neem oil, in different types of paediatric burns.
A retrospective review was conducted over the complete healing course of 9 paediatric patients with a mean age of 8.17±3.35 (1-11 years), presenting mixed, partial or full-thickness burns. The treatment applied by the wound care specialist consisted of daily cleansing of the wound with a saline solution and application of 1 Primary Wound Dressing on the whole wound surface. There was no application of a secondary dressing. The time to heal, wound size, ease of handling, pain and complications were recorded. Procedural and background pain were observed in six of the patients older than 5 years (mean age 9.6±2.39, range 8-11 years). Due to the small number of patients examined during the period studied, it was not possible to perform statistical analyses.
The mean wound size was 50.76±48.32cm2 (4.63-132.0cm2). A rapid induction of granulation tissue and re-epithelialisation was observed. Time to complete healing was 16.6±4.69 days (10-22 days). No complications related to wound infection was observed. The 6 patients older than five years reported a strong relief of pain, from an initial value of 7-8 out of 10 to 0 out of 10 within the first week of treatment. This remained at the 0 out of 10 level during the second and third weeks of treatment.
This retrospective, non-controlled examination suggests that 1 Primary Wound Dressing could be an effective therapy for the treatment of burn wounds, with benefits including pain reduction and simplicity of use. Further evaluations with a larger population are required to document the effectiveness of this plant-derived wound dressing in a controlled fashion.
There were no external sources of funding for this study. F. Carnevali is a researcher and co-inventor of 1 Primary Wound Dressing®.
观察一种植物源伤口敷料(1号初级伤口敷料®),即金丝桃与印楝油的混合物,在不同类型儿童烧伤中的疗效。
对9例平均年龄为8.17±3.35岁(1 - 11岁)的儿童烧伤患者的完整愈合过程进行回顾性研究,这些患者的烧伤类型包括混合性、部分厚度或全层厚度烧伤。伤口护理专家采用的治疗方法包括每天用生理盐水清洗伤口,并在整个伤口表面涂抹1号初级伤口敷料。未使用二次敷料。记录愈合时间、伤口大小、操作便利性、疼痛情况和并发症。6例5岁以上患者(平均年龄9.6±2.39岁,范围8 - 11岁)观察到了操作过程中的疼痛和背景疼痛。由于在研究期间检查的患者数量较少,无法进行统计分析。
平均伤口面积为50.76±48.32平方厘米(4.63 - 132.0平方厘米)。观察到肉芽组织迅速形成和上皮再形成。完全愈合时间为16.6±4.69天(10 - 22天)。未观察到与伤口感染相关的并发症。6例5岁以上患者报告疼痛明显减轻,从治疗第一周时初始的10分制中的7 - 8分降至0分。在治疗的第二周和第三周,疼痛评分维持在0分。
这项回顾性、非对照研究表明,1号初级伤口敷料可能是治疗烧伤创面的有效疗法,其益处包括减轻疼痛和使用简便。需要对更多人群进行进一步评估,以对照方式记录这种植物源伤口敷料的有效性。
本研究没有外部资金来源。F. 卡尔内瓦利是1号初级伤口敷料®的研究者和共同发明人。