端粒长度相关因素的综合述评及其对生物行为研究的意义。
An integrative review of factors associated with telomere length and implications for biobehavioral research.
机构信息
Angela R. Starkweather, PhD, ACNP-BC, CNRN, is Associate Professor, School of Nursing, Virginia Commonwealth University, Richmond. Areej A. Alhaeeri, BS, is Graduate Student, School of Medicine, Virginia Commonwealth University, Richmond. Alison Montpetit, PhD, RN, is Assistant Professor, School of Nursing, Virginia Commonwealth University, Richmond. Jenni Brumelle, PhD, is Postdoctoral Fellow, School of Medicine, Virginia Commonwealth University, Richmond. Kristin Filler, RN, BS, is Doctoral Student Fellow; Marty Montpetit, PhD, is Assistant Professor; Lathika Mohanraj, PhD, is Postdoctoral Fellow; Debra E. Lyon, PhD, RN, FNP-BC, FNAP, FAAN, is Associate Dean for Research, School of Nursing, Virginia Commonwealth University, Richmond. Colleen K. Jackson-Cook, PhD, is Professor, School of Medicine, Virginia Commonwealth University, Richmond.
出版信息
Nurs Res. 2014 Jan-Feb;63(1):36-50. doi: 10.1097/NNR.0000000000000009.
BACKGROUND
Although telomere shortening occurs as a natural part of aging, there is now a robust body of research that suggests that there is a relationship between psychosocial, environmental, and behavioral factors and changes in telomere length. These factors need to be considered when integrating telomere measurement in biobehavioral research studies.
OBJECTIVES
This article provides a brief summary of the known facts about telomere biology and an integrative review of current human research studies that assessed relationships between psychosocial, environmental, or behavioral factors and telomere length.
METHODS
An integrative review was conducted to examine human research studies that focused on psychosocial, environmental, and behavioral factors affecting telomere length and telomerase activity using the electronic databases PubMed/Medline and CINAHL from 2003 to the present. In addition to the known individual factors that are associated with telomere length, the results of the integrative review suggest that perceived stress, childhood adversities, major depressive disorder, educational attainment, physical activity, and sleep duration should also be measured.
DISCUSSION
Multiple factors have been shown to affect telomere length. To advance understanding of the role of telomere length in health and disease risk, it will be important to further elucidate the mechanisms that contribute to telomere shortening.
背景
尽管端粒缩短是衰老过程中的自然现象，但现在有大量研究表明，心理社会、环境和行为因素与端粒长度的变化之间存在关联。在将端粒测量纳入生物行为研究时，需要考虑这些因素。
目的
本文简要总结了端粒生物学的已知事实，并综合回顾了当前评估心理社会、环境或行为因素与端粒长度之间关系的人类研究。
方法
采用电子数据库 PubMed/Medline 和 CINAHL ，对 2003 年至今关注影响端粒长度和端粒酶活性的心理社会、环境和行为因素的人类研究进行综合回顾。除了已知与端粒长度相关的个体因素外，综合回顾的结果还表明，应测量感知压力、童年逆境、重度抑郁症、教育程度、身体活动和睡眠时间。
讨论
多种因素已被证明会影响端粒长度。为了进一步了解端粒长度在健康和疾病风险中的作用，阐明导致端粒缩短的机制将非常重要。
Zotero 插件