MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Chem Commun (Camb). 2014 Feb 7;50(10):1262-4. doi: 10.1039/c3cc47431c.
A room-temperature Pd(II)-catalyzed regioselective chlorination reaction has been developed for a facile one-pot synthesis of a broad range of 2-chlorophenols. The reaction demonstrates an excellent regioselectivity and reactivity for C-H chlorination. This reaction represents one of the rare examples of mild C-H functionalization at ambient temperature.
发展了一种室温下 Pd(II)催化的区域选择性氯化反应，可方便地一锅法合成广泛的 2-氯苯酚。该反应对 C-H 氯化具有优异的区域选择性和反应活性。该反应代表了温和条件下在环境温度下实现 C-H 功能化的罕见实例之一。
