Carlini Raúl, Obrador Gregorio, Campistrús Nieves, Andrade Liliana, Chifflet Liliana, Bregman Rachel, Locatelli Alberto, Correa-Rotter Ricardo, Poblete Hugo
Nefrologia. 2014;34(1):96-104. doi: 10.3265/Nefrologia.pre2013.Oct.12234. Epub 2013 Dec 12.
Anemia almost invariably occurs in patients with chronic kidney disease. Limited data are available regarding anemia management in Latin American (LA) hemodialysis (HD) patients.
To evaluate the results of the first anemia survey of the Anemia Committee of the SLANH.
This is a multinational, voluntary survey that collected anemia management data from adult HD patients from independent, non-chain owned HD units, between 09/2009 and 03/2010. T-test, ANOVA, chi-square test and multivariate logistic regression were used for statistical analysis.
The survey received responses from 134 HD units of 16 countries providing data from 9,025 patients. Mean values of Hb, ferritin, and transferrin saturation (TSAT) were 10.5 ± 1.8 g/dL, 570 ± 539 µg/l, and 29.8 ± 15%, respectively. Only 32.7% of patients were within the Hb target of 10.5-12.0 g/dL (46.3% were below and 21.1% above). Erythropoietin-stimulating agents (ESAs) were administered to 84.3% patients and 68.3% received intravenous iron (IV). Iron deficiency (TSAT≤20%) was present in 27.5% patients and among those receiving erythropoietin, 47% did not achieve Hb target. The independent variables associated with the lowest Hb level (<10.5 g/dL) were: female gender, TSAT<25% and age<50 years.
According to these results, nearly half of LA chronic HD patients did not achieve the recommended Hb target despite wide use of ESAs and IV iron.
慢性肾脏病患者几乎都会出现贫血。关于拉丁美洲(LA)血液透析(HD)患者贫血管理的数据有限。
评估拉丁美洲血液透析和肾脏病学会贫血委员会首次贫血调查的结果。
这是一项跨国自愿调查,收集了2009年9月至2010年3月期间来自独立、非连锁血液透析单位的成年血液透析患者的贫血管理数据。采用t检验、方差分析、卡方检验和多因素逻辑回归进行统计分析。
该调查收到了来自16个国家134个血液透析单位的回复,提供了9025名患者的数据。血红蛋白(Hb)、铁蛋白和转铁蛋白饱和度(TSAT)的平均值分别为10.5±1.8 g/dL、570±539 µg/l和29.8±15%。只有32.7%的患者Hb水平达到10.5 - 12.0 g/dL的目标(46.3%低于目标,21.1%高于目标)。84.3%的患者使用了促红细胞生成素(ESA),68.3%接受了静脉铁剂(IV)治疗。27.5%的患者存在缺铁(TSAT≤20%),在接受促红细胞生成素治疗的患者中,47%未达到Hb目标。与最低Hb水平(<10.5 g/dL)相关的独立变量为:女性、TSAT<25%和年龄<50岁。
根据这些结果,尽管广泛使用了ESA和静脉铁剂,但近一半的拉丁美洲慢性血液透析患者未达到推荐的Hb目标。