Pu Ke, Luo Ting, Li Juan, Tang Qian, Feng Yang, Yang Guodong
Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Statesboro Office, Southeast Medical Group, Atlanta, GA, 30022, US.
BMC Public Health. 2025 Feb 27;25(1):804. doi: 10.1186/s12889-025-21832-2.
The association between periodontitis and gastrointestinal tract (GIT) cancer has undergone extensive investigation. However, there is ongoing controversy regarding the impact of periodontitis on the incidence and mortality rates among GIT cancer patients. This study aims to clarify the relationship between periodontitis and the risk as well as mortality rates of GIT cancer.
The data utilized in this study were obtained from the National Health and Nutrition Examination Survey (NHANES) database for the years 2009-2014, which included a total of 10,706 participants from the United States. The incidence and mortality rates of GIT cancer were analyzed in relation to periodontitis. To ensure the reliability of the results, additional adjustments for covariates and stratification analyses were conducted.
In the multivariate logistic regression analysis, various variables such as age, sex, race, BMI, income, education, smoking, alcohol consumption, hypertension, hyperlipidemia, and diabetes mellitus were adjusted for. The analysis revealed no positive association between periodontitis and an increased risk of total cancer or GIT cancer including colorectal cancer. However, periodontitis was found to be significantly associated with higher mortality rates among participants for all-cause (HR: 1.58; 95% CI: 1.26-2.00; P < 0.001), GIT cancer (HR: 1.65; 95% CI: 1.24-2.20; P < 0.001), and colorectal cancer (HR: 1.65; 95% CI: 1.24-2.19; P < 0.001) individually.
The study demonstrates that periodontitis is not associated with an increased risk of incidence for total cancer, or GIT cancer including colorectal cancer. However, it is significantly associated with a higher risk of mortality for all-cause, GIT cancer, and colorectal cancer among participants in the NHANES study.
牙周炎与胃肠道（GIT）癌症之间的关联已得到广泛研究。然而，关于牙周炎对GIT癌症患者发病率和死亡率的影响仍存在争议。本研究旨在阐明牙周炎与GIT癌症风险及死亡率之间的关系。
本研究使用的数据来自2009 - 2014年的美国国家健康与营养检查调查（NHANES）数据库，共纳入来自美国的10706名参与者。分析了GIT癌症的发病率和死亡率与牙周炎的关系。为确保结果的可靠性，对协变量进行了额外调整并进行分层分析。
在多变量逻辑回归分析中，对年龄、性别、种族、体重指数、收入、教育程度、吸烟、饮酒、高血压、高脂血症和糖尿病等各种变量进行了调整。分析显示，牙周炎与包括结直肠癌在内的所有癌症或GIT癌症风险增加之间无正相关。然而，发现牙周炎与全因死亡率（HR：1.58；95%CI：1.26 - 2.00；P < 0.001）、GIT癌症（HR：1.65；95%CI：1.24 - 2.20；P < 0.001）和结直肠癌（HR：1.65；95%CI：1.24 - 2.19；P < 0.001）的死亡率显著相关。
该研究表明，牙周炎与所有癌症或包括结直肠癌在内的GIT癌症发病率增加无关。然而，在NHANES研究的参与者中，它与全因、GIT癌症和结直肠癌的较高死亡风险显著相关。
