[复发性阴道念珠菌病女性外周血中的嗜酸性粒细胞增多]

[Eosinophilia in peripheral blood of women with recurrent vaginal candidiasis].

作者信息

Queiroz Filho José, Gonçalves Ana Katherine, Cavalcante Geraldo Barroso, Pessoa Daliana Caldas, Eleutério José, Giraldo Paulo César, Sales Valéria Soraya de Farias

出版信息

Rev Bras Ginecol Obstet. 2013 Oct;35(10):453-7. doi: 10.1590/s0100-72032013001000005.

DOI:10.1590/s0100-72032013001000005

PMID:24337057

Abstract

PURPOSE

To quantify the number of defense cells and immunoglobulin E (IgE) levels in peripheral blood sampled from women with recurrent vulvovaginal candidiasis.

METHODS

A cross-sectional study was conducted on 60 women, 40 with vulvovaginal candidiasis and 20 controls. The defense cells were identified using an impedance system combined with flow cytometry and total and specific IgE was measured by chemiluminescence. The Mann-Whitney test was used for nominal variables and the Spearman test was used to determine the correlation of IgE concentration and eosinophils in peripheral blood.

RESULTS

The number of eosinophils in peripheral blood from patients with recurrent vulvovaginal candidiasis, 302.60 (± 253.07), was significantly higher compared to control, 175.75 (± 109.24) (p=0.037). Serum levels of total and specific IgE were similar in the groups of women with and without recurrent vulvovaginal candidiasis (p=0.361). However, there was a moderate positive correlation between eosinophils and total serum IgE in the candidiasis group (r=0.25).

CONCLUSION

Women with recurrent vulvovaginal candidiasis are more likely to have eosinophils in peripheral blood.

摘要

目的

对外阴阴道假丝酵母菌病复发的女性外周血中的防御细胞数量和免疫球蛋白E（IgE）水平进行量化。

方法

对60名女性进行了一项横断面研究，其中40名患有外阴阴道假丝酵母菌病，20名作为对照。使用阻抗系统结合流式细胞术鉴定防御细胞，并通过化学发光法测量总IgE和特异性IgE。对名义变量使用曼-惠特尼检验，使用斯皮尔曼检验确定外周血中IgE浓度与嗜酸性粒细胞的相关性。

结果

复发性外阴阴道假丝酵母菌病患者外周血中的嗜酸性粒细胞数量为302.60（±253.07），显著高于对照组的175.75（±109.24）（p = 0.037）。有和没有复发性外阴阴道假丝酵母菌病的女性组中总IgE和特异性IgE的血清水平相似（p = 0.361）。然而，假丝酵母菌病组中嗜酸性粒细胞与血清总IgE之间存在中度正相关（r = 0.25）。