Pirklbauer M, Gruber J
Univ.Klinik für Innere Medizin VI, Medizinische Universität Innsbruck, Anichstr. 35, 6020, Innsbruck, Österreich.
Z Rheumatol. 2014 Mar;73(2):180-3. doi: 10.1007/s00393-013-1308-5.
A female patient developed systemic rash, lung edema, electrocardiogram (ECG) abnormalities and fulminant hepatitis with partial liver failure 4 weeks after the start of sulfasalazine treatment. Peripheral T-cell activation, a positive PCR test for human herpesvirus (HHV) 6 as well as eosinophilia in bronchial lavage and a differential blood count were also present. After initiation of systemic corticosteroid therapy and cessation of accompanying medication the clinical symptoms and abnormal laboratory test levels were gradually resolved. A DRESS syndrome (drug rash with eosinophilia and systemic symptoms) was confirmed in accordance with the diagnostic criteria.
一名女性患者在开始使用柳氮磺胺吡啶治疗4周后出现全身性皮疹、肺水肿、心电图异常以及暴发性肝炎伴部分肝衰竭。还存在外周T细胞活化、人疱疹病毒（HHV）6的聚合酶链反应（PCR）检测呈阳性，以及支气管灌洗中的嗜酸性粒细胞增多和血常规异常。在开始全身皮质类固醇治疗并停用伴随药物后，临床症状和异常实验室检查水平逐渐得到缓解。根据诊断标准确诊为药物超敏反应伴嗜酸性粒细胞增多和全身症状综合征（DRESS综合征）。
