TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours.
作者信息
Lindsey Janet C, Schwalbe Ed C, Potluri Sandeep, Bailey Simon, Williamson Daniel, Clifford Steven C
机构信息
Northern Institute for Cancer Research, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
出版信息
Acta Neuropathol. 2014 Feb;127(2):307-9. doi: 10.1007/s00401-013-1225-3. Epub 2013 Dec 12.
Abstract
摘要
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TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours.端粒酶逆转录酶（TERT）启动子突变和异常高甲基化与髓母细胞瘤中表达升高相关，并是大多数非婴儿期 Sonic Hedgehog（SHH）亚组肿瘤的特征。
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本文引用的文献
1
TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas.端粒酶逆转录酶（TERT）启动子突变而非甲基化是成人胶质瘤中端粒酶逆转录酶上调的主要机制。
Acta Neuropathol. 2013 Dec;126(6):939-41. doi: 10.1007/s00401-013-1203-9. Epub 2013 Oct 31.
2
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.TERT 启动子突变在 SHH 亚组髓母细胞瘤中高度复发。
Acta Neuropathol. 2013 Dec;126(6):917-29. doi: 10.1007/s00401-013-1198-2. Epub 2013 Oct 31.
3
Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.TERT 启动子突变在儿童和成人神经系统肿瘤中的分布。
Acta Neuropathol. 2013 Dec;126(6):907-15. doi: 10.1007/s00401-013-1195-5. Epub 2013 Oct 24.
4
Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays.利用高密度DNA甲基化阵列对少量存档肿瘤材料中的髓母细胞瘤进行稳健的分子亚组分析和拷贝数分析。
Acta Neuropathol. 2013 Jun;125(6):913-6. doi: 10.1007/s00401-013-1126-5. Epub 2013 May 14.
5
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.TERT 启动子甲基化与儿童脑肿瘤的风险分层：一项综合基因组学和分子研究。
Lancet Oncol. 2013 May;14(6):534-42. doi: 10.1016/S1470-2045(13)70110-4. Epub 2013 Apr 16.
6
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.TERT 启动子突变在神经胶质瘤和一小部分源自自我更新率低的细胞的肿瘤中频繁发生。
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6. doi: 10.1073/pnas.1303607110. Epub 2013 Mar 25.
7
Highly recurrent TERT promoter mutations in human melanoma.人类黑色素瘤中高度复发的 TERT 启动子突变。
Science. 2013 Feb 22;339(6122):957-9. doi: 10.1126/science.1229259. Epub 2013 Jan 24.
8
DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies.对髓母细胞瘤进行 DNA 甲基化分析可对其进行强有力的亚分类，并使用福尔马林固定的活检提高预后预测能力。
Acta Neuropathol. 2013 Mar;125(3):359-71. doi: 10.1007/s00401-012-1077-2. Epub 2013 Jan 5.
9
Medulloblastomics: the end of the beginning.髓母细胞瘤组学：开始的结束。
Nat Rev Cancer. 2012 Dec;12(12):818-34. doi: 10.1038/nrc3410.
10
Molecular subgroups of medulloblastoma: the current consensus.髓母细胞瘤的分子亚型：当前共识。
Acta Neuropathol. 2012 Apr;123(4):465-72. doi: 10.1007/s00401-011-0922-z. Epub 2011 Dec 2.
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