Furuya Fumihiko, Shimura Hiroki, Yokomichi Hiroshi, Takahashi Kazuya, Akiyama Daiichiro, Asakawa Chikako, Okamura Ayako, Motosugi Ai, Haraguchi Kazutaka, Yamagata Zentaro, Kobayashi Tetsuro
Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan,
Clin Exp Nephrol. 2014 Oct;18(5):778-83. doi: 10.1007/s10157-013-0923-4. Epub 2013 Dec 12.
Elevated levels of neutrophil gelatinase-associated lipocalin (NGAL) have been reported in patients with cardiovascular disease (CVD), heart failure, and stroke. We assessed the relationships between serum levels of NGAL and the prevalence of CVD, and clarified the prognostic usefulness of systemic NGAL levels in hemodialysis (HD) patients.
Eighty-eight HD patients were followed up for 1 year. Logistic regression analyses were used to investigate the relationship between de novo CVD status and NGAL levels as well as other risk factors.
During follow-up, CVD events occurred in 20 patients. Initial serum levels of NGAL and brain natriuretic peptide of HD patients with de novo CVD were significantly higher than those of HD patients without de novo CVD. Multivariate logistic regression analyses showed that initial serum levels of NGAL were independent risk factors for de novo CVD in HD patients. When patients were classified on the basis of NGAL quartiles, multiple logistic regression analyses demonstrated that the highest quartile of NGAL level showed an increased odds ratio for the prevalence of CVD.
These findings suggest that NGAL levels can be used to detect the prevalence of CVD in HD patients with or without diabetes.
据报道，心血管疾病（CVD）、心力衰竭和中风患者的中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平升高。我们评估了血清NGAL水平与CVD患病率之间的关系，并阐明了全身NGAL水平在血液透析（HD）患者中的预后价值。
对88例HD患者进行了1年的随访。采用逻辑回归分析来研究新发CVD状态与NGAL水平以及其他危险因素之间的关系。
在随访期间，20例患者发生了CVD事件。新发CVD的HD患者的初始血清NGAL和脑钠肽水平显著高于无新发CVD的HD患者。多变量逻辑回归分析表明，初始血清NGAL水平是HD患者新发CVD的独立危险因素。当根据NGAL四分位数对患者进行分类时，多变量逻辑回归分析表明，NGAL水平最高的四分位数显示CVD患病率的比值比增加。
这些发现表明，NGAL水平可用于检测有或无糖尿病的HD患者中CVD的患病率。
