Viennois Emilie, Zhao Yuan, Merlin Didier
*Institute for Biomedical Sciences, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia; †Atlanta Veterans Affairs Medical Center, Decatur, Georgia; and ‡Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
Inflamm Bowel Dis. 2015 Oct;21(10):2467-74. doi: 10.1097/MIB.0000000000000444.
Diagnostics of inflammatory bowel diseases (IBDs) currently relies on a combination of biological and morphological tests. The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and severity assessment, and therapeutic outcomes. Laboratory biomarkers can be used in the diagnosis and management of IBD, but none of them has been proven to be ideal. Increasing efforts are being made to discover new biomarkers that can discriminate between the types of IBD, predict future responses to treatment, and aid in differential diagnosis, treatment planning, and prognosis prediction. This review addresses the potential for current biomarkers and the emergence of the concept of biomarker signatures in IBD diagnostic and personalized medicine.
炎症性肠病(IBD)的诊断目前依赖于生物学和形态学检查的结合。当前的诊断方法对医生来说仍然是一项严峻挑战,部分原因在于其具有侵入性,还在于其在诊断、预后、疾病活动度和严重程度评估以及治疗效果方面存在局限性。实验室生物标志物可用于IBD的诊断和管理,但尚无一种被证明是理想的。人们正在加大力度发现能够区分IBD类型、预测未来治疗反应并有助于鉴别诊断、治疗规划和预后预测的新生物标志物。本综述探讨了当前生物标志物的潜力以及IBD诊断和个性化医疗中生物标志物特征概念的出现。