Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.
J Neural Transm (Vienna). 2014 May;121(5):543-7. doi: 10.1007/s00702-013-1138-2. Epub 2013 Dec 14.
Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK inhibitor U0126 mitigates brain damage in rodent models of ischemic stroke. Here we show that the newer MEK inhibitor PD184161 reduces cell death and altered gene expression in cultured neurons and mice undergoing excitotoxicity, and has similar protective effects in a mouse model of stroke. This further supports ERK inhibition as a potential treatment for stroke.
缺血性中风是主要的死亡原因。此前已经表明，用 MEK 抑制剂 U0126 阻断细胞外信号调节激酶 (ERK) 的激活可减轻缺血性中风啮齿动物模型中的脑损伤。在这里，我们表明，新型 MEK 抑制剂 PD184161 可减少培养神经元和经历兴奋性毒性的小鼠中的细胞死亡和改变基因表达，并且在中风小鼠模型中具有相似的保护作用。这进一步支持 ERK 抑制作为中风治疗的潜在手段。
