Krug D, Debus J, Sterzing F
Klinik für Radioonkologie und Strahlentherapie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland,
Radiologe. 2014 Feb;54(2):145-51. doi: 10.1007/s00117-013-2550-1.
The term cancer of unknown primary (CUP) encompasses a group of entities which differ to a great extent regarding etiology, prognosis and therapeutic management.
The aim of the study was an elaboration of the role of radiotherapy in CUP syndrome.
Systematic literature search and specification of the available treatment options.
Radiotherapy is an integral part of interdisciplinary management approaches for patients with CUP in both curative and palliative situations. Radio-oncological techniques, such as intensity-modulated radiotherapy and stereotactic body radiotherapy increase the therapeutic window. Modern diagnostic modalities from radiology and nuclear medicine are the cornerstone of radiotherapeutic interventions, especially in terms of target volume definition and pretherapeutic staging. In the interdisciplinary setting radiation oncology offers the possibility of curative and often organ preserving approaches in patients with axillary and cervical CUP. In addition, improvement and preservation of quality of life can be achieved in patients with metastatic disease.
Radiation oncology is a crucial component of the interdisciplinary management of patients with CUP. Therapeutic decisions in patients with CUP should be made in an interdisciplinary setting.
原发灶不明的癌症（CUP）这一术语涵盖了一组在病因、预后和治疗管理方面存在很大差异的实体。
本研究的目的是阐述放射治疗在CUP综合征中的作用。
系统检索文献并明确可用的治疗方案。
在根治性和姑息性情况下，放射治疗都是CUP患者多学科管理方法的一个组成部分。调强放疗和立体定向体部放疗等放射肿瘤学技术拓宽了治疗窗口。放射学和核医学的现代诊断方法是放射治疗干预的基石，特别是在靶区体积定义和治疗前分期方面。在多学科环境中，放射肿瘤学为腋窝和颈部CUP患者提供了根治性且常能保留器官的治疗方法。此外，转移性疾病患者的生活质量也可得到改善和维持。
放射肿瘤学是CUP患者多学科管理的关键组成部分。CUP患者的治疗决策应在多学科环境中做出。
