Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675, Munich, Germany.
Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany.
Strahlenther Onkol. 2018 Mar;194(3):185-195. doi: 10.1007/s00066-017-1227-5. Epub 2017 Nov 1.
Pancreatic cancer is one of the most aggressive human tumors and the incidence has increased over the last 6 years. In the majority of cases the disease is already in an advanced stage at the time of diagnosis where surgery, the only curative treatment, is no longer an option and explains the still abysmal overall survival. The role of radiation therapy as treatment option for patients with pancreatic cancer is controversially discussed although radiation oncology has emerged as a central pillar in the combined oncological treatment.
The present manuscript gives an overview of advanced radiotherapeutic strategies in the context of chemotherapy and surgery according to the current American Society of Clinical Oncology (ASCO) guidelines in comparison with the German guidelines and to elucidate the role of radiation therapy for the treatment of pancreatic cancer.
Advanced modern radiotherapeutic techniques in combination with individualized high-precision radiation concepts are new therapeutic approaches for pancreatic cancer in a multimodal setting with tolerable side effects. Several clinical studies together with experimental approaches are in process, to deliver further evidence and ultimately allow true personalized medicine.
胰腺癌是最具侵袭性的人类肿瘤之一，在过去的 6 年中，其发病率一直在上升。在大多数情况下，疾病在诊断时已经处于晚期，此时手术（唯一的治愈性治疗方法）已不再可行，这也解释了总体生存率仍然极低的原因。尽管放射肿瘤学已成为综合肿瘤治疗的核心支柱，但作为胰腺癌治疗选择的放射治疗的作用仍存在争议。
本论文根据美国临床肿瘤学会（ASCO）的现行指南，与德国指南相比，概述了化疗和手术背景下的先进放射治疗策略，并阐明了放射治疗在胰腺癌治疗中的作用。
先进的现代放射治疗技术与个体化高精度放射概念相结合，是一种新的多模式治疗胰腺癌的方法，副作用可耐受。为了提供更多的证据，并最终实现真正的个体化医疗，目前正在进行多项临床研究和实验研究。
