Yiallouras Christos, Mylonas Nicos, Damianou Christakis
MEDSONIC LTD, Limassol, Cyprus.
Int J Comput Assist Radiol Surg. 2014 Jul;9(4):745-53. doi: 10.1007/s11548-013-0964-x. Epub 2013 Dec 13.
High-intensity focused ultrasound (HIFU) is a promising treatment method for many common cancers, including prostate cancer. Magnetic resonance image (MRI) guidance of HIFU permits targeting and monitoring of therapy. A prototype MRI-compatible positioning device that navigates a HIFU transducer was designed, fabricated and tested.
The positioning device has two PC-controlled and one manually driven stage that allow endorectal access to the prostate. The positioning device was constructed using a 3-D rapid prototype manufacturing device. Software was developed that controls the motion of the positioning device and enables activation of a HIFU transducer. In vitro testing of the system was performed in a 1.5T MRI scanner using ex vivo turkey tissue. Optical encoders were employed to enhance the accuracy of this positioning device.
The positioning device was successfully tested for MRI compatibility. The movement error of the positioning device is approximately 20 [Formula: see text]m. The robot has the ability to accurately move the transducer for creation of discrete and overlapping lesions.
An MRI-compatible HIFU positioning system was developed that has the ability to create thermal lesions with MRI guidance for endorectal treatment of prostate cancer.
高强度聚焦超声（HIFU）是一种用于治疗包括前列腺癌在内的多种常见癌症的有前景的治疗方法。HIFU的磁共振成像（MRI）引导可实现治疗的靶向定位和监测。设计、制造并测试了一种与MRI兼容的用于操控HIFU换能器的定位装置。
该定位装置有两个由计算机控制的平台和一个手动驱动的平台，可经直肠进入前列腺。定位装置采用三维快速原型制造设备构建。开发了控制定位装置运动并能激活HIFU换能器的软件。使用离体火鸡组织在1.5T MRI扫描仪中对该系统进行体外测试。采用光学编码器提高该定位装置的精度。
成功测试了定位装置的MRI兼容性。定位装置的运动误差约为20微米。该机器人能够精确移动换能器以形成离散和重叠的病灶。
开发了一种与MRI兼容的HIFU定位系统，该系统能够在MRI引导下产生热损伤，用于经直肠治疗前列腺癌。
