Dorenberg Eric J, Courivaud Frédéric, Ring Eva, Hald Kirsten, Jakobsen Jarl Å, Fosse Erik, Hol Per Kristian
Department of Radiology, Division of Diagnostics and Intervention, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Minim Invasive Ther Allied Technol. 2013 Apr;22(2):73-9. doi: 10.3109/13645706.2012.702672. Epub 2012 Jul 16.
The purpose of this study was to evaluate the feasibility and safety of the Sonalleve high-intensity focused ultrasound (HIFU; Philips Healthcare, Vantaa, Finland) system in ablating uterine fibroids in a 3T magnet.
Seven women were included in this study. Treatment was performed according to the manufacturer's recommendation. Technical data describing the HIFU procedures were collected. On MR images at baseline, immediately and 30 days after ablation, we evaluated the volumes of the uterus, the dominant fibroid and the ablation zone. The Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire was used to assess potential clinical response.
The procedure was technically feasible in all patients. The median number of sonications performed during each procedure was 20 (range 2-27) per patient, the maximum temperature in all sonication cells was about 68°C. The median procedure time was 156 minutes (range 95-164). The non-perfused volume after treatment ranged from 1 to 27 ml and was unchanged or decreased in all but one patient at 30 days follow-up. There were no major adverse events.
In our 3T magnet the system was able to heat tissue and induce areas of non-enhancement within uterine fibroids without major complications. Clinical benefit remains to be proven.
本研究的目的是评估Sonalleve高强度聚焦超声（HIFU；飞利浦医疗保健公司，芬兰万塔）系统在3T磁共振成像仪中消融子宫肌瘤的可行性和安全性。
本研究纳入了7名女性。治疗按照制造商的建议进行。收集了描述HIFU治疗过程的技术数据。在基线、消融后即刻及30天的磁共振图像上，我们评估了子宫、主要肌瘤及消融区的体积。使用子宫肌瘤症状与生活质量（UFS-QOL）问卷评估潜在的临床反应。
该治疗方法在所有患者中技术上均可行。每位患者每次治疗的中位超声照射次数为20次（范围为2 - 27次），所有超声照射单元中的最高温度约为68°C。中位治疗时间为156分钟（范围为95 - 164分钟）。治疗后无灌注体积范围为1至27毫升，在30天随访时，除1例患者外，所有患者的无灌注体积未改变或减小。未发生重大不良事件。
在我们的3T磁共振成像仪中，该系统能够加热组织并在子宫肌瘤内诱导出无强化区域，且无重大并发症。临床益处仍有待证实。
