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CCN1 promotes vascular endothelial growth factor secretion through αvβ 3 integrin receptors in breast cancer.

作者信息

Espinoza Ingrid, Menendez Javier A, Kvp Chandra Mohan, Lupu Ruth

机构信息

Department of Medicine and Experimental Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

出版信息

J Cell Commun Signal. 2014 Mar;8(1):23-7. doi: 10.1007/s12079-013-0214-6. Epub 2013 Dec 12.

DOI:10.1007/s12079-013-0214-6
PMID:24338441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3972397/
Abstract
摘要

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2
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Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells.鉴定CCN1（CYR61）中一个新的整合素αvβ3结合位点，该位点对血管内皮细胞的促血管生成活性至关重要。
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本文引用的文献

1
Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis.在基于细胞的蛋白质组学筛选中鉴定由基质金属蛋白酶2（MMP-2）加工的候选血管生成抑制剂：MMP-2蛋白水解对血管内皮生长因子（VEGF）/肝素亲和调节肽（多效生长因子）和VEGF/结缔组织生长因子血管生成抑制复合物的破坏
Mol Cell Biol. 2007 Dec;27(24):8454-65. doi: 10.1128/MCB.00821-07. Epub 2007 Oct 1.
2
The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration.血管生成因子CCN1促进循环CD34+祖细胞的黏附与迁移：在血管生成和内皮再生中的潜在作用
Blood. 2007 Aug 1;110(3):877-85. doi: 10.1182/blood-2006-07-036202. Epub 2007 Apr 11.
3
AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer.αVβ3整联蛋白调节乳腺癌中由这里调节蛋白（HRG）诱导的细胞增殖和存活。
Oncogene. 2005 May 26;24(23):3759-73. doi: 10.1038/sj.onc.1208452.
4
A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.一种新型的由CYR61触发的“CYR61-αvβ3整合素环”通过激活ERK1/ERK2丝裂原活化蛋白激酶信号通路来调节乳腺癌细胞的存活和化学敏感性。
Oncogene. 2005 Jan 27;24(5):761-79. doi: 10.1038/sj.onc.1208238.
5
Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells.鉴定CCN1（CYR61）中一个新的整合素αvβ3结合位点，该位点对血管内皮细胞的促血管生成活性至关重要。
J Biol Chem. 2004 Oct 15;279(42):44166-76. doi: 10.1074/jbc.M406813200. Epub 2004 Aug 10.
6
Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247.RGD拟肽药物S137和S247的抗转移特性
Clin Exp Metastasis. 2004;21(2):129-38. doi: 10.1023/b:clin.0000024764.93092.5f.
7
A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis.一种关于CCN（CYR61/CTGF/NOV）蛋白在肿瘤发生中作用的结构学研究方法。
Cancer Cell Int. 2003 Aug 22;3(1):15. doi: 10.1186/1475-2867-3-15.
8
Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).结缔组织生长因子（CTGF）和富含半胱氨酸的61蛋白（CYR61）对血管生成和内皮细胞功能的调节
Angiogenesis. 2002;5(3):153-65. doi: 10.1023/a:1023823803510.
9
Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment.乳腺癌诱导的血管生成：多种机制及微环境的作用
Breast Cancer Res. 2003;5(3):140-6. doi: 10.1186/bcr589. Epub 2003 Mar 10.
10
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development.结缔组织生长因子在骨骼发育过程中协调软骨形成和血管生成。
Development. 2003 Jun;130(12):2779-91. doi: 10.1242/dev.00505.