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Use of Cox regression with treatment status as a time-dependent covariate to re-analyze survival benefit excludes immortal time bias effect in patients with glioblastoma who received prolonged adjuvant treatment with valganciclovir.

作者信息

Söderberg-Naucler Cecilia, Peredo Inti, Rahbar Afsar, Hansson Fredrik, Nordlund Anders, Stragliotto Giuseppe

机构信息

Department of Medicine Solna Unit for Experimental Medicine Cell and Molecular Immunology, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

出版信息

Int J Cancer. 2014 Jul 1;135(1):248-9. doi: 10.1002/ijc.28663. Epub 2014 Jan 6.

DOI:10.1002/ijc.28663
PMID:24338548
Abstract
摘要

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1
Use of Cox regression with treatment status as a time-dependent covariate to re-analyze survival benefit excludes immortal time bias effect in patients with glioblastoma who received prolonged adjuvant treatment with valganciclovir.将治疗状态作为时间依存性协变量使用Cox回归重新分析生存获益，可排除接受缬更昔洛韦延长辅助治疗的胶质母细胞瘤患者的不朽时间偏倚效应。
Int J Cancer. 2014 Jul 1;135(1):248-9. doi: 10.1002/ijc.28663. Epub 2014 Jan 6.
2
Immortal time bias in retrospective analysis: is there a survival benefit in patients with glioblastoma who received prolonged treatment of adjuvant valganciclovir?回顾性分析中的不朽时间偏倚：接受延长辅助缬更昔洛韦治疗的胶质母细胞瘤患者是否有生存获益？
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3
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4
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Neurosurgery. 2014 Feb;74(2):N23-4. doi: 10.1227/01.neu.0000442982.91829.da.
5
Does valganciclovir have a role in glioblastoma therapy?缬更昔洛韦在胶质母细胞瘤治疗中起作用吗？
Neuro Oncol. 2014 Mar;16(3):330-1. doi: 10.1093/neuonc/nou009.
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Cytomegalovirus and glioblastoma: a review of evidence for their association and indications for testing and treatment.巨细胞病毒与胶质母细胞瘤：关于它们之间关联的证据以及检测与治疗指征的综述
J Neuropathol Exp Neurol. 2014 Nov;73(11):994-8. doi: 10.1097/NEN.0000000000000125.
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Controversies in neuro-oncology: does valganciclovir have a role in the treatment of high-grade gliomas?神经肿瘤学中的争议：缬更昔洛韦在高级别胶质瘤治疗中是否发挥作用？
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[Questionable effect of antiviral therapy in malignant brain tumors].[抗病毒治疗对恶性脑肿瘤的可疑疗效]
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CMV infection and glioma, a highly controversial concept struggling in the clinical arena.巨细胞病毒感染与胶质瘤，这是一个在临床领域颇具争议的概念。
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[Inconclusive data].[数据不明确]
Lakartidningen. 2014;111(27-28):1192.

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Role of cytomegalovirus in glioblastoma development: promoter or culprit?巨细胞病毒在胶质母细胞瘤发展中的作用：促进因素还是罪魁祸首？
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Clinical implications of cytomegalovirus in glioblastoma progression and therapy.巨细胞病毒在胶质母细胞瘤进展和治疗中的临床意义
NPJ Precis Oncol. 2024 Sep 29;8(1):213. doi: 10.1038/s41698-024-00709-4.
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Cytomegalovirus and Glioblastoma: A Review of the Biological Associations and Therapeutic Strategies.巨细胞病毒与胶质母细胞瘤：生物学关联及治疗策略综述
J Clin Med. 2022 Sep 4;11(17):5221. doi: 10.3390/jcm11175221.
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Cytomegalovirus in Haematological Tumours.血液肿瘤中的巨细胞病毒。
Front Immunol. 2021 Oct 18;12:703256. doi: 10.3389/fimmu.2021.703256. eCollection 2021.
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Human cytomegalovirus seropositivity is associated with decreased survival in glioblastoma patients.人巨细胞病毒血清阳性与胶质母细胞瘤患者生存率降低相关。
Neurooncol Adv. 2019 Sep 7;1(1):vdz020. doi: 10.1093/noajnl/vdz020. eCollection 2019 May-Dec.
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Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review.模仿病毒性脑炎的胶质母细胞瘤对阿昔洛韦有反应：病例系列及文献综述
Front Oncol. 2019 Jan 22;9:8. doi: 10.3389/fonc.2019.00008. eCollection 2019.
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The role of CMV in glioblastoma and implications for immunotherapeutic strategies.巨细胞病毒在胶质母细胞瘤中的作用及其对免疫治疗策略的影响。
Oncoimmunology. 2018 Oct 16;8(1):e1514921. doi: 10.1080/2162402X.2018.1514921. eCollection 2019.
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The Viral Connection to Glioblastoma.病毒与胶质母细胞瘤的关联
Curr Infect Dis Rep. 2017 Feb;19(2):5. doi: 10.1007/s11908-017-0563-z.
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Valganciclovir and bevacizumab for recurrent glioblastoma: A single-institution experience.缬更昔洛韦与贝伐单抗治疗复发性胶质母细胞瘤：单机构经验
Mol Clin Oncol. 2016 Feb;4(2):154-158. doi: 10.3892/mco.2015.692. Epub 2015 Dec 4.
10
Cytomegalovirus and glioblastoma; controversies and opportunities.巨细胞病毒与胶质母细胞瘤：争议与机遇
J Neurooncol. 2015 Jul;123(3):465-71. doi: 10.1007/s11060-015-1734-0. Epub 2015 Feb 15.