Calvieri S, Fattorossi A
Acta Derm Venereol. 1986;66(6):497-501.
A psoriasis patient developed erythroderma after the withdrawal of a self-administered chronic topical glucocorticoid therapy. A marked expansion of cells with the morphological and phenotypic features of large granular lymphocytes was noticed in peripheral blood. Functional investigations revealed that these cells responded poorly to polyclonal activators and exhibited antibody-dependent cellular cytotoxicity and natural killer activity. Blood abnormalities completely subsided in about two months in the absence of any cytostatic therapy and coincided with the recovery from the erythroderma and the spreading of classical psoriatic plaque lesions. This excluded an underlying malignant process. This patient represents the first report of a previously undescribed immunological disorder in psoriatic erythroderma.
一名银屑病患者在自行停用慢性外用糖皮质激素治疗后发生了红皮病。在外周血中发现具有大颗粒淋巴细胞形态和表型特征的细胞显著增多。功能研究显示，这些细胞对多克隆激活剂反应不佳，并表现出抗体依赖性细胞毒性和自然杀伤活性。在未进行任何细胞抑制治疗的情况下，血液异常在大约两个月内完全消退，同时红皮病恢复，经典银屑病斑块病变扩散。这排除了潜在的恶性过程。该患者代表了银屑病红皮病中一种先前未描述的免疫紊乱的首次报告。
