Xue Changying, Wong Darice Y, Kasko Andrea M
Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, 4121 Eng V, Los Angeles, CA, 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA, 90095, USA.
Adv Mater. 2014 Mar 12;26(10):1577-83. doi: 10.1002/adma.201304591. Epub 2013 Dec 12.
Complex substrate control is demonstrated with a dual-tone hydrogel photoresist. By exposing a photodegradable hydrogel to UV light through a photomask, both swollen and eroded micropatterns with a decreased modulus can be created on the surface under different exposure conditions. This provides an important tool for investigating the synergistic effects of spatially heterogeneous mechanical and topological cues on cell behavior.
通过一种双色调水凝胶光刻胶展示了复杂的底物控制。通过光掩模将可光降解水凝胶暴露于紫外光下,在不同的曝光条件下,可以在表面上创建模量降低的肿胀和侵蚀微图案。这为研究空间异质机械和拓扑线索对细胞行为的协同效应提供了一个重要工具。