Arthritis Care Res (Hoboken). 2014 Jun;66(6):943-8. doi: 10.1002/acr.22247.
To investigate the utility of questionnaire-based assessment of cognitive function and behavioral/emotional symptoms to screen for neurocognitive dysfunction in childhood-onset systemic lupus erythematosus (cSLE).
Forty children with cSLE and 24 healthy controls ages 10–16 years were enrolled. Formal neurocognitive testing (FNCT) was done to determine cognitive performance in 4 key areas that appear to be sensitive to the adverse effects of cSLE: attention, working memory, psychomotor speed, and visuoconstructional ability. Paper and pencil questionnaires sampling cognitive functioning and behavioral/emotional symptoms were also completed: the Subjective Awareness of Neuropsychological Deficits for Children (SAND-C) questionnaire by patients, and the Child Behavioral Checklist and the Behavior Rating Inventory of Executive Function (BRIEF) by parents.
Domain and summary scores of the BRIEF and SAND-C correlated modestly with participants' performance on FNCT. Questionnaire ratings did not discriminate subjects with different levels of cognitive ability as measured by FNCT.
Contrary to some reports in adults with SLE, self-administered questionnaires of cognitive functioning and parent ratings of executive functioning do not appear well suited to replace FNCT in screening for neurocognitive impairment of children and adolescents with cSLE. However, they may provide information that is complementary to FNCT and therefore play a useful role in clinical followup.
研究基于问卷的认知功能和行为/情绪症状评估在儿童发病的系统性红斑狼疮（cSLE）中筛查神经认知功能障碍的效用。
纳入了 40 名 10-16 岁的 cSLE 患儿和 24 名健康对照者。进行了正式的神经认知测试（FNCT），以确定 4 个关键领域的认知表现，这些领域似乎对 cSLE 的不良影响敏感：注意力、工作记忆、心理运动速度和视空间构建能力。还完成了评估认知功能和行为/情绪症状的纸笔问卷：患者的儿童神经心理缺陷主观意识量表（SAND-C）问卷，以及父母的儿童行为检查表和行为评定量表-执行功能（BRIEF）。
BRIEF 和 SAND-C 的领域和总分与 FNCT 参与者的表现呈中度相关。问卷评分不能区分 FNCT 测量的认知能力不同水平的受试者。
与一些 SLE 成人的报告相反，认知功能的自我报告问卷和父母对执行功能的评分似乎不适合替代 FNCT 筛查儿童和青少年 cSLE 的神经认知障碍。然而，它们可能提供与 FNCT 互补的信息，因此在临床随访中发挥有用的作用。
